-
Tytuł:
-
Exposure to a Mycobacterial Antigen, ESAT-6, Exacerbates Granulomatous and Fibrotic Changes in a Multiwall Carbon Nanotube Model of Chronic Pulmonary Disease.
-
Autorzy:
-
Malur A
Barna BP
Patel J
McPeek M
Wingard CJ
Dobbs L
Thomassen MJ
-
Źródło:
-
Journal of nanomedicine & nanotechnology [J Nanomed Nanotechnol] 2015 Dec; Vol. 6 (6). Date of Electronic Publication: 2015 Dec 27.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: Los Angeles, CA : OMICS Publishing Group
-
References:
-
Am J Respir Cell Mol Biol. 2011 Nov;45(5):899-905. (PMID: 21659662)
Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L341-53. (PMID: 21131395)
Cell Metab. 2007 Aug;6(2):137-43. (PMID: 17681149)
Nat Rev Immunol. 2014 Feb;14(2):81-93. (PMID: 24445666)
Am J Respir Cell Mol Biol. 2010 Aug;43(2):142-51. (PMID: 19738159)
Am J Respir Cell Mol Biol. 2015 Nov;53(5):585-600. (PMID: 26121236)
Toxicol Sci. 2004 Jan;77(1):126-34. (PMID: 14514958)
Toxicol Sci. 2015 Mar;144(1):51-64. (PMID: 25527334)
Chest. 2007 May;131(5):1414-23. (PMID: 17400664)
Infect Immun. 2007 Jan;75(1):527-30. (PMID: 17088357)
Diagn Microbiol Infect Dis. 2014 Apr;78(4):391-7. (PMID: 24485599)
Toxicology. 2010 Mar 10;269(2-3):136-47. (PMID: 19857541)
Clin Respir J. 2009 Oct;3(4):229-38. (PMID: 20298409)
Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1311-8. (PMID: 14977630)
Crit Rev Toxicol. 2006 Mar;36(3):189-217. (PMID: 16686422)
Circ Res. 2010 May 28;106(10):1559-69. (PMID: 20508200)
Environ Health Perspect. 2010 Apr;118(4):499-504. (PMID: 20368128)
J Clin Immunol. 2013 Feb;33(2):446-55. (PMID: 23073617)
Part Fibre Toxicol. 2011 Aug 18;8:24. (PMID: 21851604)
Ann N Y Acad Sci. 1986;465:632-42. (PMID: 3460401)
Arch Toxicol. 2015 Apr;89(4):621-33. (PMID: 25510677)
Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708. (PMID: 15951334)
J Control Release. 2005 May 5;104(1):67-77. (PMID: 15866335)
Nat Rev Rheumatol. 2011 Jul 12;7(8):457-67. (PMID: 21750528)
Chest. 1999 Nov;116(5):1183-93. (PMID: 10559074)
Environ Health Prev Med. 2009 Jul;14(4):223-5. (PMID: 19568840)
Immune Netw. 2015 Jun;15(3):142-9. (PMID: 26140046)
Respir Res. 2013 Jan 23;14:7. (PMID: 23343389)
J Immunol. 2005 Feb 15;174(4):2174-84. (PMID: 15699149)
Int J Mol Sci. 2013 Dec 06;14 (12 ):23858-71. (PMID: 24322444)
J Immunol. 2006 Nov 1;177(9):6353-60. (PMID: 17056566)
Am J Respir Cell Mol Biol. 2011 Oct;45(4):858-66. (PMID: 21398620)
Am J Respir Crit Care Med. 2001 Dec 15;164(12):2243-7. (PMID: 11751194)
Science. 2013 Feb 1;339(6119):535-9. (PMID: 23372006)
EBioMedicine. 2015 Oct 09;2(11):1697-704. (PMID: 27014740)
Clin Exp Immunol. 2007 Dec;150(3):460-8. (PMID: 17924974)
Am Fam Physician. 2009 May 15;79(10):879-86. (PMID: 19496388)
-
Grant Information:
-
R15 ES022462 United States ES NIEHS NIH HHS; R21 HL077652 United States HL NHLBI NIH HHS
-
Contributed Indexing:
-
Keywords: Carbon nanotube; Fibrosis; Granuloma; Mycobacterial antigen
-
Entry Date(s):
-
Date Created: 20160329 Latest Revision: 20201001
-
Update Code:
-
20240104
-
PubMed Central ID:
-
PMC4807875
-
DOI:
-
10.4172/2157-7439.1000340
-
PMID:
-
27019768
-
Recent studies suggest additive effects of environmental pollutants and microbial antigens on respiratory disease. We established a granuloma model in which instilled multiwall carbon nanotubes (MWCNT) elicit granulomatous pathology. We hypothesized that mycobacterial antigen ESAT-6, a T cell activator associated with tuberculosis and sarcoidosis, might alter pathology. Wild-type C57Bl/6 mice received MWCNT with or without ESAT-6 peptide. Controls received vehicle (surfactant-PBS) or ESAT-6 alone. Mice were evaluated 60 days later for granulomas, fibrosis, and bronchoalveolar lavage (BAL) cell expression of inflammatory mediators (CCL2, MMP-12, and Osteopontin). Results indicated increased granulomas, fibrosis, and inflammatory mediators in mice receiving the combination of MWCNT+ESAT-6 compared to MWCNT or vehicle alone. ESAT-6 alone showed no significant effect on these pathological endpoints. However, CD3 (+) lymphocyte infiltration of lung tissue increased with MWCNT+ESAT-6 versus MWCNT alone. Findings suggest that concurrent exposure to microbial antigen and MWCNT exacerbates chronic pulmonary disease.