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Tytuł pozycji:

Comparison of GeneXpert MTB/RIF and conventional methods for the diagnosis of tuberculosis in Kosovo.

Tytuł :
Comparison of GeneXpert MTB/RIF and conventional methods for the diagnosis of tuberculosis in Kosovo.
Autorzy :
Bajrami R; National Institute of Public Health of Kosovo and University of Prishtina, Prishina, Kosovo. .
Mulliqi G
Kurti A
Lila G
Raka L
Pokaż więcej
Źródło :
Journal of infection in developing countries [J Infect Dev Ctries] 2016 Apr 28; Vol. 10 (4), pp. 418-22. Date of Electronic Publication: 2016 Apr 28.
Typ publikacji :
Comparative Study; Evaluation Study; Journal Article
Język :
English
Journal Info :
Publisher: Open Learning on Enteric Pathogens Country of Publication: Italy NLM ID: 101305410 Publication Model: Electronic Cited Medium: Internet ISSN: 1972-2680 (Electronic) Linking ISSN: 19722680 NLM ISO Abbreviation: J Infect Dev Ctries Subsets: MEDLINE
Imprint Name(s) :
Original Publication: [Italy?] : Open Learning on Enteric Pathogens
MeSH Terms :
Drug Resistance, Bacterial*
Antitubercular Agents/*pharmacology
Bacteriological Techniques/*methods
Molecular Diagnostic Techniques/*methods
Mycobacterium/*isolation & purification
Rifampin/*pharmacology
Tuberculosis/*diagnosis
Adult ; Aged ; Cross-Sectional Studies ; Europe ; Female ; Humans ; Kosovo ; Male ; Microscopy/methods ; Middle Aged ; Mycobacterium/drug effects ; Prospective Studies
Substance Nomenclature :
0 (Antitubercular Agents)
VJT6J7R4TR (Rifampin)
Entry Date(s) :
Date Created: 20160501 Date Completed: 20170201 Latest Revision: 20191210
Update Code :
20200716
DOI :
10.3855/jidc.7569
PMID :
27131007
Czasopismo naukowe
Introduction: Tuberculosis (TB) is a major public health problem worldwide, with the highest mortality occurring in developing countries. The burden of TB in Kosovo is among the highest in Europe. The aim of this study was to compare Cepheid GeneXpert MTB/RIF assay for direct detection of Mycobacterium tuberculosis complex (MTBC) and rifampin (RIF) resistance with conventional methods.
Methodology: A cross-sectional design to evaluate diagnostic tests was carried out at the Department of Microbiology, National Institute of Public Health of Kosovo and Lung Clinic, from January to June 2014. The detection of MTBC and RIF resistance using the Xpert MTB/RIF assay was assessed in 116 specimens received from 110 patients suspected of having TB and compared with conventional smear microscopy and culture methods.
Results: Fifty-eight patients (52.7%) were male, and the mean age was 48.6±18.1 years. Twenty-nine patients (26.4%) had underlying lung diseases. Of the 116 specimens investigated, 28 (24.1%) were MTBC-positive by culture, while 34 (29.3%) were positive by Xpert assay. Two samples showed false-negative Xpert results. Compared with culture, the Xpert assay achieved 82.3% (95% CI: 65.5%-93.2%) sensitivity, and 97.6% (95% CI: 91.5%-99.7%) specificity. GeneXpert could detect 11.7% and 50% additional positive cases as compared to Lowenstein-Jensen culture and smear microscopy, respectively. Three cases with resistance to rifampin were detected from clinical isolates.
Conclusions: The GeneXpert MTB/RIF assay is a helpful tool for rapid diagnosis and prompt treatment of TB.

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