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Tytuł pozycji:

Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer.

Tytuł :
Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer.
Autorzy :
Almeida AL; Ribeirão Preto Medical School, University of São Paulo, Brazil.
Bernardes MV; Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Feitosa MR; Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Peria FM; Ribeirão Preto Medical School, University of São Paulo, Brazil.
Tirapelli DP; Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Rocha JJ; Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Feres O; Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Pokaż więcej
Źródło :
Acta cirurgica brasileira [Acta Cir Bras] 2016; Vol. 31 Suppl 1, pp. 13-8.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Sao Paulo : Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina
Original Publication: São Paulo : A Sociedade,
MeSH Terms :
Adenoma/*blood
Carcinoma/*blood
Colorectal Neoplasms/*blood
MicroRNAs/*blood
Adenoma/genetics ; Age Factors ; Biomarkers, Tumor/blood ; Carcinoembryonic Antigen/blood ; Carcinoma/genetics ; Case-Control Studies ; Colorectal Neoplasms/genetics ; Female ; Humans ; Male ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Prognosis ; Prospective Studies ; Real-Time Polymerase Chain Reaction ; Reference Values
Substance Nomenclature :
0 (Biomarkers, Tumor)
0 (Carcinoembryonic Antigen)
0 (MIRN126 microRNA, human)
0 (MIRN21 microRNA, human)
0 (MIRN34 microRNA, human)
0 (MicroRNAs)
Entry Date(s) :
Date Created: 20160505 Date Completed: 20170530 Latest Revision: 20170530
Update Code :
20210210
DOI :
10.1590/S0102-86502016001300004
PMID :
27142899
Czasopismo naukowe
Purpose: This paper describes the ability of miRNA value predict oncological outcomes in CRC patients and correlates to clinical and pathologic variables.
Methods: We prospectively analyzed the serological expression of microRNA-21, microRNA-34a, and microRNA-126 in 37 stage II - IV CRC patients and correlate to seven fit counterparts. Serological microRNAs were extracted using the miRNeasy Mini Kit(r) (Qiagen, Hilden, Germany). Quantification of microRNAs was performed using TaqMan Master Mix(r) reagent (Applied Biosystems, USA).
Results: We obtained serological underexpression microRNA-21, microRNA-34a, and microRNA-126 in CRC group. However, miRNAs serological values do not impact prognosis. Furthermore, miRNAs was not influenced by CEA values, TNM staging, and histological subtype.
Conclusion: Despite lower expression of miR-21, miR-34a and miR-126 in the CRC group, no association with poor prognosis was found.

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