-
Tytuł:
-
Comparative evaluation of oncologic outcomes in colon cancer.
-
Autorzy:
-
Bernardes MV; Ribeirão Preto Medical School, University of São Paulo, Brazil.
Feitosa MR; Ribeirão Preto Medical School, University of São Paulo, Brazil.
Peria FM; Ribeirão Preto Medical School, University of São Paulo, Brazil.
Tirapelli DP; Ribeirão Preto Medical School, University of São Paulo, Brazil.
Rocha JJ; Ribeirão Preto Medical School, University of São Paulo, Brazil.
Feres O; Ribeirão Preto Medical School, University of São Paulo, Brazil.
-
Źródło:
-
Acta cirurgica brasileira [Acta Cir Bras] 2016; Vol. 31 Suppl 1, pp. 34-9.
-
Typ publikacji:
-
Comparative Study; Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: Sao Paulo : Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina
Original Publication: São Paulo : A Sociedade,
-
MeSH Terms:
-
Colonic Neoplasms/*mortality
Colonic Neoplasms/*surgery
Adult ; Aged ; Aged, 80 and over ; Brazil ; Carcinoembryonic Antigen/blood ; Colonic Neoplasms/pathology ; Databases, Factual ; Developed Countries ; Developing Countries ; Female ; Humans ; Income ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local ; Prognosis ; Prospective Studies ; Risk Factors ; Time Factors
-
Substance Nomenclature:
-
0 (Carcinoembryonic Antigen)
-
Entry Date(s):
-
Date Created: 20160505 Date Completed: 20170530 Latest Revision: 20170530
-
Update Code:
-
20240104
-
DOI:
-
10.1590/S0102-86502016001300008
-
PMID:
-
27142903
-
Purpose: In this paper we report clinical variables on colon cancer series. Oncological outcomes were compared to low-income and high-income countries.
Methods: We analysed a prospective database of 51 colon cancer patients submitted to primary tumor resection between 2010 and 2011, showing clinical variables and oncologic outcomes.
Results: R0 resection obtained in 80.4%, 21.6% of patients was TNM stage IV, and only 13.7% showed TNM stage I. Disease-free survival was 32 months, overall survival was 46 months, and the tumoral recurrence rate was 9.8%. Univariate analysis showed association of serum CEA levels ≥ 5 ng/dl (p= 0.004), presence of metastasis at diagnosis (p= 0.012), compromised surgical margins (p < 0.001) and poorer tumor differentiation (p= 0.041) to death. Multivariate analysis identified compromised surgical margins as an independent risk factor for death due to colon cancer (P=0.003; odds ratio=0.36; 95% confidence interval=0.004-0.33). Nowadays, 62.7% of patients are alive.
Conclusion: Recurrence rate, disease-free survival and overall survival was similar to those observed in more developed countries. Serum CEA levels ≥ 5 ng/dl, the presence of metastasis at diagnosis, compromised surgical margins and poorer tumor differentiation were associated with death. A compromised surgical margin was the only independent risk factor for death.
