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Tytuł:
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Lung function decline in asthma patients with elevated bronchial CD8, CD4 and CD3 cells.
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Autorzy:
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den Otter I; Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands I.den_.
Willems LN; Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
van Schadewijk A; Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
van Wijngaarden S; Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Janssen K; Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
de Jeu RC; Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
Sont JK; Dept of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands.
Sterk PJ; Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands Dept of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Hiemstra PS; Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands.
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Źródło:
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The European respiratory journal [Eur Respir J] 2016 Aug; Vol. 48 (2), pp. 393-402. Date of Electronic Publication: 2016 May 26.
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Typ publikacji:
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Journal Article; Observational Study; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Sheffield, United Kingdom : European Respiratory Society
Original Publication: Copenhagen : Published jointly by the Society and Munksgaard, 1988-
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MeSH Terms:
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Respiratory Function Tests*
Asthma/*physiopathology
CD3 Complex/*metabolism
CD4-Positive T-Lymphocytes/*cytology
CD8-Positive T-Lymphocytes/*cytology
Granzymes/*metabolism
Adult ; Asthma/therapy ; Biopsy ; Bronchi/physiopathology ; Bronchial Hyperreactivity/physiopathology ; Bronchial Provocation Tests ; Bronchodilator Agents/pharmacology ; Cohort Studies ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Forced Expiratory Volume ; Humans ; Inflammation ; Longitudinal Studies ; Male ; Middle Aged ; Phenotype ; Prospective Studies ; Spirometry
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Substance Nomenclature:
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0 (Bronchodilator Agents)
0 (CD3 Complex)
EC 3.4.21.- (Granzymes)
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Entry Date(s):
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Date Created: 20160528 Date Completed: 20180319 Latest Revision: 20180508
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Update Code:
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20240104
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DOI:
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10.1183/13993003.01525-2015
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PMID:
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27230446
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Which inflammatory markers in the bronchial mucosa of asthma patients are associated with decline of lung function during 14 years of prospective follow-up?To address this question, 19 mild-to-moderate, atopic asthmatic patients underwent spirometry and bronchoscopy at baseline and after 14 years of follow-up (t=14). Baseline bronchial biopsies were analysed for reticular layer thickness, eosinophil cationic protein (EG2), mast cell tryptase (AA1), CD3, CD4 and CD8. Follow-up biopsies were stained for EG2, AA1, neutrophil elastase, CD3, CD4, CD8, CD20, granzyme B, CD68, DC-SIGN, Ki67 and mucins.Decline in forced expiratory volume in 1 s (FEV1) % predicted was highest in patients with high CD8 (p=0.01, both pre- and post-bronchodilator) or high CD4 counts at baseline (p=0.04 pre-bronchodilator, p=0.03 post-bronchodilator). Patients with high CD8, CD3 or granzyme B counts at t=14 also exhibited faster decline in FEV1 (p=0.00 CD8 pre-bronchodilator, p=0.04 CD8 post-bronchodilator, p=0.01 granzyme B pre-bronchodilator, and p<0.01 CD3 pre-bronchodilator).Long-term lung function decline in asthma is associated with elevation of bronchial CD8 and CD4 at baseline, and CD8, CD3 and granzyme B at follow-up. This suggests that high-risk groups can be identified on the basis of inflammatory phenotypes.
(Copyright ©ERS 2016.)
Comment in: Eur Respir J. 2016 Aug;48(2):287-90. (PMID: 27478181)
