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Tytuł pozycji:

Reference ranges for serum periostin in a population without asthma or chronic obstructive pulmonary disease.

Tytuł:
Reference ranges for serum periostin in a population without asthma or chronic obstructive pulmonary disease.
Autorzy:
Caswell-Smith R; Medical Research Institute of New Zealand, Wellington, New Zealand.; Victoria University of Wellington, Wellington, New Zealand.
Hosking A; Medical Research Institute of New Zealand, Wellington, New Zealand.; University of Auckland, Auckland, New Zealand.
Cripps T; Medical Research Institute of New Zealand, Wellington, New Zealand.
Holweg C; Genentech Inc, San Francisco, CA, USA.
Matthews J; Genentech Inc, San Francisco, CA, USA.
Holliday M; Medical Research Institute of New Zealand, Wellington, New Zealand.
Maillot C; Medical Research Institute of New Zealand, Wellington, New Zealand.
Fingleton J; Medical Research Institute of New Zealand, Wellington, New Zealand.
Weatherall M; Medical Research Institute of New Zealand, Wellington, New Zealand.; University of Otago, Wellington, New Zealand.
Braithwaite I; Medical Research Institute of New Zealand, Wellington, New Zealand.; Victoria University of Wellington, Wellington, New Zealand.; Capital & Coast District Health Board, Wellington, New Zealand.
Beasley R; Medical Research Institute of New Zealand, Wellington, New Zealand. .; Victoria University of Wellington, Wellington, New Zealand. .; Capital & Coast District Health Board, Wellington, New Zealand. .
Corporate Authors:
Periostin Study Team
Źródło:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2016 Oct; Vol. 46 (10), pp. 1303-14. Date of Electronic Publication: 2016 Jun 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: Oxford : Blackwell Scientific Publications, c1989-
MeSH Terms:
Cell Adhesion Molecules/*blood
Adolescent ; Adult ; Aged ; Asthma/blood ; Biomarkers ; Cross-Sectional Studies ; Exhalation ; Female ; Humans ; Leukocyte Count ; Male ; Middle Aged ; Nitric Oxide/metabolism ; Population Surveillance ; Pulmonary Disease, Chronic Obstructive/blood ; Reference Values ; Respiratory Function Tests ; Young Adult
Contributed Indexing:
Investigator: T Charles; L Eastlake; D Fabian; T Mallon; C Munro; J Pilcher; A Pritchard; M Richards; J Riley; P Shirtcliffe; M Stretch; M Williams; J Brumm; M Handigol; J Olsen; K Yen
Keywords: adult; non-asthma; non-chronic obstructive pulmonary disease; periostin; reference range
Molecular Sequence:
ANZCTR ACTRN12614000047695
Substance Nomenclature:
0 (Biomarkers)
0 (Cell Adhesion Molecules)
0 (POSTN protein, human)
31C4KY9ESH (Nitric Oxide)
Entry Date(s):
Date Created: 20160531 Date Completed: 20171222 Latest Revision: 20220330
Update Code:
20240104
DOI:
10.1111/cea.12763
PMID:
27237923
Czasopismo naukowe
Background: The clinical utility of serum periostin as a type 2 biomarker in asthma is limited by lack of reference range values derived from a population without respiratory disease.
Objective: To derive age- and sex-related reference intervals for serum periostin from an adult population without asthma or COPD.
Methods: Serum periostin levels were measured in 480 individuals, comprising 60 female and 60 male adults in each of the 18- to 30-year, 31- to 45-year, 46- to 60-year and 61- to 75-year age groups. Key exclusion criteria included a doctor's diagnosis of asthma, chronic bronchitis or COPD, and a history of wheezing or use of respiratory inhalers in the last 12 months. The distribution of periostin and logarithm-transformed periostin levels was derived, and 90% confidence intervals for an individual prediction were calculated.
Results: The distribution of serum periostin was right skewed with a mean (SD) periostin of 51.2 (11.9) ng/mL, median (IQR) 50.1 (43.1 to 56.9) ng/mL and range 28.1 to 136.4 ng/mL. There was no association between logarithm periostin and age or sex, although levels were low in current smokers. The 90% confidence limits for periostin were 35.0 and 71.1 ng/mL.
Conclusions and Clinical Relevance: Serum periostin levels in adults without asthma or COPD are similar to those in adults with asthma. Serum periostin measurements do not need to be adjusted to take account of a patient's age or sex, although levels are lower in current smokers. Reference values for serum periostin levels in adults without asthma or COPD are provided.
(© 2016 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons Ltd.)
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