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Tytuł pozycji:

Evidence for age-associated disinhibition of the wake drive provided by scoring principal components of the resting EEG spectrum in sleep-provoking conditions.

Tytuł :
Evidence for age-associated disinhibition of the wake drive provided by scoring principal components of the resting EEG spectrum in sleep-provoking conditions.
Autorzy :
Putilov AA; a Group of Biomedical Systems Math-Modeling, Research Institute for Molecular Biology and Biophysics , Novosibirsk , Russia.
Donskaya OG; a Group of Biomedical Systems Math-Modeling, Research Institute for Molecular Biology and Biophysics , Novosibirsk , Russia.
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Źródło :
Chronobiology international [Chronobiol Int] 2016; Vol. 33 (8), pp. 995-1008. Date of Electronic Publication: 2016 Jun 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: London : Informa Healthcare
Original Publication: Oxford ; New York : Pergamon Press, c1984-
MeSH Terms :
Electroencephalography*
Sleep/*physiology
Wakefulness/*physiology
Adult ; Aged ; Aging ; Brain ; Humans ; Male ; Middle Aged ; Principal Component Analysis ; Young Adult
Contributed Indexing :
Keywords: Aging*; EEG*; principal component analysis*; sleep and wake promoting processes*; sleep debt*; sleep pressure*; sleep-wake regulation*; sleepiness*
Entry Date(s) :
Date Created: 20160603 Date Completed: 20180110 Latest Revision: 20180201
Update Code :
20210623
DOI :
10.1080/07420528.2016.1189431
PMID :
27253971
Czasopismo naukowe
Age-associated changes in different bandwidths of the human electroencephalographic (EEG) spectrum are well documented, but their functional significance is poorly understood. This spectrum seems to represent summation of simultaneous influences of several sleep-wake regulatory processes. Scoring of its orthogonal (uncorrelated) principal components can help in separation of the brain signatures of these processes. In particular, the opposite age-associated changes were documented for scores on the two largest (1st and 2nd) principal components of the sleep EEG spectrum. A decrease of the first score and an increase of the second score can reflect, respectively, the weakening of the sleep drive and disinhibition of the opposing wake drive with age. In order to support the suggestion of age-associated disinhibition of the wake drive from the antagonistic influence of the sleep drive, we analyzed principal component scores of the resting EEG spectra obtained in sleep deprivation experiments with 81 healthy young adults aged between 19 and 26 and 40 healthy older adults aged between 45 and 66 years. At the second day of the sleep deprivation experiments, frontal scores on the 1st principal component of the EEG spectrum demonstrated an age-associated reduction of response to eyes closed relaxation. Scores on the 2nd principal component were either initially increased during wakefulness or less responsive to such sleep-provoking conditions (frontal and occipital scores, respectively). These results are in line with the suggestion of disinhibition of the wake drive with age. They provide an explanation of why older adults are less vulnerable to sleep deprivation than young adults.

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