Senescence Can Be BETter without the SASP?

Tytuł:: Senescence Can Be BETter without the SASP?
Autorzy:: Vizioli MG; Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom. Institute of Cancer Sciences College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Adams PD; Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom. Institute of Cancer Sciences College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. .
Źródło:: Cancer discovery [Cancer Discov] 2016 Jun; Vol. 6 (6), pp. 576-8.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Comment
Język:: English
Imprint Name(s):: Original Publication: Philadelphia, PA : American Association for Cancer Research
MeSH Terms:: Phenotype*
Cellular Senescence/*genetics
Chromatin ; Humans
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Nature. 2010 Dec 23;468(7327):1119-23. (PMID: 21068722)
N Engl J Med. 2012 Jan 19;366(3):207-15. (PMID: 22256804)
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Nature. 2016 Feb 11;530(7589):184-9. (PMID: 26840489)
Cancer Discov. 2016 Jun;6(6):612-29. (PMID: 27099234)
Grant Information:: 16566 United Kingdom CRUK_ Cancer Research UK; P01 AG031862 United States AG NIA NIH HHS
Substance Nomenclature:: 0 (Chromatin)
Entry Date(s):: Date Created: 20160605 Date Completed: 20170323 Latest Revision: 20240210
Update Code:: 20240210
PubMed Central ID:: PMC6489500
DOI:: 10.1158/2159-8290.CD-16-0485
PMID:: 27261480
: Czasopismo naukowe

Global remodeling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this issue, Tasdemir and colleagues show that the epigenetic regulator BRD4 is required for expression of the proinflammatory senescence-associated secretory phenotype and immune clearance of senescent cells in vitro and in vivo Their results could be useful in the design of novel therapies to treat aging-related diseases, including cancer.Cancer Discov; 6(6); 576-8. ©2016 AACR.See related article by Tasdemir et al., p. 612.
(©2016 American Association for Cancer Research.)

Comment on: Cancer Discov. 2016 Jun;6(6):612-29. (PMID: 27099234)

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