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Tytuł pozycji:

High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22.

Tytuł:
High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22.
Autorzy:
Gulhane M; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Murray L; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Lourie R; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Tong H; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Sheng YH; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Wang R; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Kang A; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.
Schreiber V; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Wong KY; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Magor G; Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Denman S; The Commonwealth Scientific and Industrial Research Organization, St Lucia, Brisbane, Australia.
Begun J; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Florin TH; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Perkins A; Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Cuív PÓ; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.
McGuckin MA; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Hasnain SZ; Immunity, Infection and Inflammation Program, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Australia.
Źródło:
Scientific reports [Sci Rep] 2016 Jun 28; Vol. 6, pp. 28990. Date of Electronic Publication: 2016 Jun 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:
Diet, High-Fat*
Stress, Physiological*
Colon/*drug effects
Epithelial Cells/*drug effects
Inflammation/*chemically induced
Interleukins/*metabolism
Intestinal Mucosa/*drug effects
Animals ; Cells, Cultured ; Colon/physiology ; Cytokines/metabolism ; Epithelial Cells/physiology ; Intestinal Mucosa/physiology ; Mice, Obese ; Mucus/metabolism ; Interleukin-22
References:
J Exp Med. 2013 Jun 3;210(6):1201-16. (PMID: 23650437)
Nat Med. 2014 Dec;20(12):1417-26. (PMID: 25362253)
Mol Nutr Food Res. 2012 Apr;56(4):524-35. (PMID: 22495981)
Gastroenterology. 2009 Nov;137(5):1716-24.e1-2. (PMID: 19706296)
Cell Host Microbe. 2008 Apr 17;3(4):213-23. (PMID: 18407065)
J Crohns Colitis. 2013 Aug;7(7):e241-8. (PMID: 23040290)
PLoS One. 2013 Aug 16;8(8):e71661. (PMID: 23977107)
Metabolism. 2008 Dec;57(12):1704-10. (PMID: 19013294)
Ital J Pediatr. 2010 Oct 01;36:66. (PMID: 20920305)
Biochem J. 2009 May 13;420(2):211-9. (PMID: 19228118)
Clin Exp Immunol. 2013 Dec;174(3):459-71. (PMID: 24028683)
Biotechniques. 2004 May;36(5):808-12. (PMID: 15152600)
Cell Metab. 2015 Apr 7;21(4):527-42. (PMID: 25863246)
J Gastroenterol Hepatol. 2010 Nov;25(11):1785-94. (PMID: 21039842)
Gut. 2016 Mar;65(3):426-36. (PMID: 26100928)
J Exp Med. 2011 May 9;208(5):893-900. (PMID: 21502330)
Inflamm Bowel Dis. 2015 May;21(5):973-84. (PMID: 25803508)
Nature. 2014 Oct 23;514(7523):508-12. (PMID: 25174708)
J Lipid Res. 2012 May;53(5):973-8. (PMID: 22394503)
J Clin Invest. 2006 Nov;116(11):3015-25. (PMID: 17053832)
Cell Host Microbe. 2012 Feb 16;11(2):140-52. (PMID: 22341463)
Gut. 2012 Apr;61(4):543-53. (PMID: 22110050)
Am J Gastroenterol. 2011 Apr;106(4):563-73. (PMID: 21468064)
PLoS One. 2010 Aug 16;5(8):e12191. (PMID: 20808947)
Nature. 2014 Oct 9;514(7521):237-41. (PMID: 25119041)
Cytokine Growth Factor Rev. 2006 Oct;17(5):367-80. (PMID: 17030002)
J Biol Chem. 2013 May 31;288(22):15830-42. (PMID: 23589307)
Gut. 2014 Jan;63(1):116-24. (PMID: 23598352)
Curr Opin Clin Nutr Metab Care. 2011 Jul;14(4):328-33. (PMID: 21587067)
Nat Rev Microbiol. 2011 Apr;9(4):265-78. (PMID: 21407243)
PLoS One. 2013 Jun 12;8(6):e65878. (PMID: 23776564)
Nature. 2012 Jul 5;487(7405):104-8. (PMID: 22722865)
Mucosal Immunol. 2011 May;4(3):354-64. (PMID: 21107311)
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71. (PMID: 23671105)
Diabetes. 2008 Jun;57(6):1470-81. (PMID: 18305141)
Development. 2002 Jun;129(11):2619-28. (PMID: 12015290)
J Immunol. 2013 May 15;190(10):5306-12. (PMID: 23585682)
Br J Nutr. 2010 Apr;103(7):1070-8. (PMID: 19930761)
PLoS Med. 2008 Mar 4;5(3):e54. (PMID: 18318598)
Cell. 2008 Sep 5;134(5):743-56. (PMID: 18775308)
Aliment Pharmacol Ther. 2010 Dec;32(11-12):1307-14. (PMID: 21050232)
J Clin Invest. 2008 Feb;118(2):534-44. (PMID: 18172556)
J Nutr. 2013 Aug;143(8):1240-7. (PMID: 23761644)
Nat Rev Mol Cell Biol. 2003 Sep;4(9):721-32. (PMID: 14506475)
Parasite Immunol. 2011 Jan;33(1):45-55. (PMID: 21155842)
Nat Med. 2008 Mar;14(3):282-9. (PMID: 18264109)
J Nutr Biochem. 2012 Oct;23 (10 ):1207-13. (PMID: 22209007)
BMC Bioinformatics. 2010 Jul 02;11:367. (PMID: 20598126)
PLoS One. 2012;7(10 ):e47713. (PMID: 23091640)
Gastroenterology. 2013 Feb;144(2):357-368.e9. (PMID: 23123183)
Diabetes Care. 2011 Aug;34(8):1809-15. (PMID: 21636801)
PLoS One. 2012;7(3):e32084. (PMID: 22427817)
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6950-5. (PMID: 19359471)
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2365-70. (PMID: 19164560)
Science. 2011 Nov 25;334(6059):1081-6. (PMID: 22116877)
Eur J Immunol. 2009 Sep;39(9):2629-35. (PMID: 19662632)
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3300-5. (PMID: 19202076)
Diabetes. 2007 Jul;56(7):1761-72. (PMID: 17456850)
Substance Nomenclature:
0 (Cytokines)
0 (Interleukins)
Entry Date(s):
Date Created: 20160629 Date Completed: 20180509 Latest Revision: 20231213
Update Code:
20240104
PubMed Central ID:
PMC4924095
DOI:
10.1038/srep28990
PMID:
27350069
Czasopismo naukowe
Prolonged high fat diets (HFD) induce low-grade chronic intestinal inflammation in mice, and diets high in saturated fat are a risk factor for the development of human inflammatory bowel diseases. We hypothesized that HFD-induced endoplasmic reticulum (ER)/oxidative stress occur in intestinal secretory goblet cells, triggering inflammatory signaling and reducing synthesis/secretion of proteins that form the protective mucus barrier. In cultured intestinal cells non-esterified long-chain saturated fatty acids directly increased oxidative/ER stress leading to protein misfolding. A prolonged HFD elevated the intestinal inflammatory cytokine signature, alongside compromised mucosal barrier integrity with a decrease in goblet cell differentiation and Muc2, a loss in the tight junction protein, claudin-1 and increased serum endotoxin levels. In Winnie mice, that develop spontaneous colitis, HFD-feeding increased ER stress, further compromised the mucosal barrier and increased the severity of colitis. In obese mice IL-22 reduced ER/oxidative stress and improved the integrity of the mucosal barrier, and reversed microbial changes associated with obesity with an increase in Akkermansia muciniphila. Consistent with epidemiological studies, our experiments suggest that HFDs are likely to impair intestinal barrier function, particularly in early life, which partially involves direct effects of free-fatty acids on intestinal cells, and this can be reversed by IL-22 therapy.

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