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Tytuł:
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C-type natriuretic peptide is closely associated to obesity in Caucasian adolescents.
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Autorzy:
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Del Ry S; Laboratory of Biochemistry and Molecular Biology, Institute of Clinical Physiology, CNR, Pisa, Italy. Electronic address: .
Cabiati M; Laboratory of Biochemistry and Molecular Biology, Institute of Clinical Physiology, CNR, Pisa, Italy.
Bianchi V; Unit of Pediatric Endocrinology and Diabetes, Dep. Clinical and Experimental Medicine, University of Pisa, Italy.
Caponi L; Translational Research Department, University of Pisa, Italy.
Maltinti M; Fondazione Toscana G. Monasterio, Pisa, Italy.
Caselli C; Laboratory of Biochemistry and Molecular Biology, Institute of Clinical Physiology, CNR, Pisa, Italy.
Kozakova M; Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Palombo C; Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Italy.
Morizzo C; Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa, Italy.
Marchetti S; Unit of Pediatric Endocrinology and Diabetes, Dep. Clinical and Experimental Medicine, University of Pisa, Italy.
Randazzo E; Unit of Pediatric Endocrinology and Diabetes, Dep. Clinical and Experimental Medicine, University of Pisa, Italy.
Clerico A; Fondazione Toscana G. Monasterio, Pisa, Italy.
Federico G; Unit of Pediatric Endocrinology and Diabetes, Dep. Clinical and Experimental Medicine, University of Pisa, Italy.
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Źródło:
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Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2016 Sep 01; Vol. 460, pp. 172-7. Date of Electronic Publication: 2016 Jul 02.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam, Elsevier.
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MeSH Terms:
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Natriuretic Peptide, C-Type/*blood
Obesity/*blood
Adolescent ; Biomarkers/blood ; Body Mass Index ; Child ; Cohort Studies ; Humans ; Natriuretic Peptides/blood ; Overweight ; ROC Curve ; Radioimmunoassay ; Risk Factors ; White People
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Contributed Indexing:
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Keywords: AGEs; Adolescents; C-type natriuretic peptide; Growth; Natriuretic peptides; Obesity
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Substance Nomenclature:
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0 (Biomarkers)
0 (Natriuretic Peptides)
127869-51-6 (Natriuretic Peptide, C-Type)
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Entry Date(s):
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Date Created: 20160706 Date Completed: 20170202 Latest Revision: 20221207
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Update Code:
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20240104
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DOI:
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10.1016/j.cca.2016.06.045
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PMID:
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27376982
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CNP is a natural regulator of adipogenesis playing a role in the development of obesity in childhood. Aim of the study was to evaluate CNP plasma levels in normal-weight (N), overweight (OW) and obese adolescents (O). Eighty two subjects (age:12.8±2.4, years) without cardiac dysfunction were enrolled and CNP plasma levels were measured by RIA. NT-proBNP, MR-proANP, AGEs, reactive hyperemia index (RHI) and standard clinical chemistry parameters were also measured. O and OW adolescents had higher values of BMI and fat mass than N. CNP levels were significantly lower in OW:4.79[3.29-21.15] and O:3.81[1.55-13.4] than in N:13.21[7.6-37.8]; p<0.0001N vs O, p=0.0003N vs OW). LogCNP values correlated significantly and inversely with BMI z-score, FM%, TF% and circulating levels of CRP, insulin, total cholesterol, LDL, and triglycerides, in addition to an inverse relationship with skin AGEs and a direct correlation with RHI. LogCNP was also inversely associated with LogNT-proBNP and LogMR-proANP values. Using ROC analysis the risk of obesity resulted significantly (p≪0.0001) associated with CNP values (AUC=0.9724). These results suggest that CNP may play a more important role than BNP and ANP related peptides, as risk marker of obesity, in addition to its involvement in adipogenesis and endothelial dysfunction.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
