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Tytuł pozycji:

Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of three new nano-sized Cu(II), Co(II) and Ni(II) chelates based on tri-dentate NOO imine ligands as precursors for metal oxides.

Tytuł :
Sonochemical synthesis, DNA binding, antimicrobial evaluation and in vitro anticancer activity of three new nano-sized Cu(II), Co(II) and Ni(II) chelates based on tri-dentate NOO imine ligands as precursors for metal oxides.
Autorzy :
Abdel-Rahman LH; Chemistry Department, Faculty of Science, Sohag University, 82534 Sohag, Egypt. Electronic address: .
Abu-Dief AM; Chemistry Department, Faculty of Science, Sohag University, 82534 Sohag, Egypt. Electronic address: .
El-Khatib RM; Chemistry Department, Faculty of Science, Sohag University, 82534 Sohag, Egypt.
Abdel-Fatah SM; Chemistry Department, Faculty of Science, Sohag University, 82534 Sohag, Egypt.
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Źródło :
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2016 Sep; Vol. 162, pp. 298-308. Date of Electronic Publication: 2016 Jun 30.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Lausanne : Elsevier Sequoia, 1987-
MeSH Terms :
Ultrasonic Waves*
DNA/*metabolism
Imines/*chemistry
Nanostructures/*chemistry
Organometallic Compounds/*chemical synthesis
Organometallic Compounds/*pharmacology
Oxides/*chemistry
Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/metabolism ; Anti-Infective Agents/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Chelating Agents/chemical synthesis ; Chelating Agents/chemistry ; Chelating Agents/metabolism ; Chelating Agents/pharmacology ; Chemistry Techniques, Synthetic ; Cobalt/chemistry ; Copper/chemistry ; Humans ; Hydrodynamics ; Kinetics ; Ligands ; MCF-7 Cells ; Nickel/chemistry ; Organometallic Compounds/chemistry ; Organometallic Compounds/metabolism
Contributed Indexing :
Keywords: Antimicrobial activity; Cytotoxic activity; DNA interaction; Nanoparticles; Synthesis; Thermal analyses
Substance Nomenclature :
0 (Anti-Infective Agents)
0 (Antineoplastic Agents)
0 (Chelating Agents)
0 (Imines)
0 (Ligands)
0 (Organometallic Compounds)
0 (Oxides)
3G0H8C9362 (Cobalt)
789U1901C5 (Copper)
7OV03QG267 (Nickel)
9007-49-2 (DNA)
Entry Date(s) :
Date Created: 20160711 Date Completed: 20170302 Latest Revision: 20171009
Update Code :
20210210
DOI :
10.1016/j.jphotobiol.2016.06.052
PMID :
27395793
Czasopismo naukowe
Three new nano sized Cu(II), Co(II) and Ni(II) complexes of imine ligand derived from the condensation of 2-amino-3-hydroxypyridine and 3-methoxysalicylaldehyde have been prepared and investigated using various chemical techniques such as NMR, elemental analysis, molar conductance, IR, electronic spectra, TGA and magnetic moment measurements. The obtained chemical analysis data showed that the synthesis of 1:1 (metal:ligand) ratio and octahedral geometry was proposed on the basis of magnetic moment and spectral data studies except the Cu(II) complex which is tetrahedral geometry. Nano-sized particles of the investigated complexes were prepared by sonochemistry method. Furthermore, metal oxides nanoparticles were gained by calcination of the prepared corresponding complexes at 500°C and their structures were characterized by powder x-ray and transmittance electron microscopy. Moreover, the free ligand, its complexes and their metal oxides have been checked in vitro against a number of bacteria and fungi in order to assess their antimicrobial activities. In addition to that, DNA binding of the prepared complexes was tested by many routes such as electronic spectra, viscosity and gel electrophoresis. The results showed that the investigated complexes could bind to DNA via an intercalative mode. The cytotoxicity of the Schiff base complexes on human colon carcinoma cells, (HCT-116 cell line) and Breast carcinoma cells, (MCF-7 cell line) showed potent cytotoxicity effect against growth of carcinoma cells compared to the clinically used Vinblastine standard.
(Copyright © 2016 Elsevier B.V. All rights reserved.)

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