-
Tytuł:
-
Retrospective analysis of factors influencing oncologic outcome in 590 patients with early-intermediate glottic cancer treated by transoral laser microsurgery.
-
Autorzy:
-
Ansarin M; Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
Cattaneo A; Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
De Benedetto L; Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
Zorzi S; Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
Lombardi F; Division of Pathology, European Institute of Oncology, Milan, Italy.
Alterio D; Division of Radiotherapy, European Institute of Oncology, Milan, Italy.
Rocca MC; Medical Oncology Division of Urogenital and Head and Neck Tumours, European Institute of Oncology, Milan, Italy.
Scelsi D; Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
Preda L; Division of Radiology, European Institute of Oncology, Milan, Italy.
Chiesa F; Department of Otolaryngology - Head and Neck Surgery, European Institute of Oncology, Milan, Italy.
Santoro L; Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
-
Źródło:
-
Head & neck [Head Neck] 2017 Jan; Vol. 39 (1), pp. 71-81. Date of Electronic Publication: 2016 Jul 25.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: New York, NY : John Wiley And Sons
Original Publication: New York, NY : J. Wiley, c1989-
-
MeSH Terms:
-
Glottis*
Laser Therapy*
Microsurgery*
Carcinoma/*surgery
Laryngeal Neoplasms/*surgery
Adult ; Aged ; Aged, 80 and over ; Carcinoma/mortality ; Carcinoma/pathology ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Laryngeal Neoplasms/mortality ; Laryngeal Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Retrospective Studies ; Survival Rate ; Treatment Outcome
-
Contributed Indexing:
-
Keywords: laryngeal cancer; organ preservation; overall survival; relapse-free survival; transoral laryngeal microsurgery
-
Entry Date(s):
-
Date Created: 20160726 Date Completed: 20180223 Latest Revision: 20220317
-
Update Code:
-
20240104
-
DOI:
-
10.1002/hed.24534
-
PMID:
-
27453475
-
Background: The purpose of this study was to identify the factors influencing oncologic outcomes for patients with early-intermediate glottic cancer treated by transoral laser microsurgery (TLM).
Methods: This was a retrospective mono-institutional study. A total of 590 patients with cTis-cT3 glottic cancer underwent TLM with curative intent.
Results: TLM alone was performed in 538 patients (91.2%) and TLM followed by adjuvant radiotherapy (RT) was done in 52 (8.8%). Five-year recurrence-free survival (RFS) and 10-year overall survival (OS) were 85.3% and 74.7%, respectively. The larynx-preservation ratio was 95.9%. In particular, from our data, we found that occult metastases were rare (1.2%); preventive tracheotomy was not necessary; the local recurrence rate of Tis was similar to that in the T2 and T3 group; and no major or lethal complications were observed.
Conclusion: Age (>60 vs ≤60), type of cordectomy (≥IV vs ≤III), status of margins, fixed arytenoid, and pathologic T classification, were the variables associated with RFS, OS, and organ-preservation rate. © 2016 Wiley Periodicals, Head Neck 39: 71-81, 2017.
(© 2016 Wiley Periodicals, Inc.)