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Tytuł:
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Incidence rate of amyloidosis in patients from a medical care program in Buenos Aires, Argentina: a prospective cohort.
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Autorzy:
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Aguirre MA; a Internal Medicine Department, Hospital Italiano de Buenos Aires , Argentina.
Boietti BR; a Internal Medicine Department, Hospital Italiano de Buenos Aires , Argentina.
Nucifora E; a Internal Medicine Department, Hospital Italiano de Buenos Aires , Argentina.
Sorroche PB; a Internal Medicine Department, Hospital Italiano de Buenos Aires , Argentina.
González Bernaldo de Quirós F; a Internal Medicine Department, Hospital Italiano de Buenos Aires , Argentina.
Giunta DH; a Internal Medicine Department, Hospital Italiano de Buenos Aires , Argentina.
Posadas-Martínez ML; a Internal Medicine Department, Hospital Italiano de Buenos Aires , Argentina.
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Źródło:
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Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2016 Sep; Vol. 23 (3), pp. 184-187. Date of Electronic Publication: 2016 Jul 28.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2015- : Abingdon, Oxford : Taylor & Francis
Original Publication: Pearl River, NY : Parthenon Pub., c1994-
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MeSH Terms:
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Registries*
Amyloidosis/*epidemiology
Adult ; Aged ; Amyloidosis/classification ; Amyloidosis/diagnosis ; Argentina/epidemiology ; Female ; Health Maintenance Organizations ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies
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Contributed Indexing:
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Keywords: AA amyloidosis; AL amyloidosis; ATTRwt amyloidosis; Incidence; incidence density; systemic amyloidosis
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Entry Date(s):
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Date Created: 20160730 Date Completed: 20170110 Latest Revision: 20170111
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Update Code:
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20240104
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DOI:
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10.1080/13506129.2016.1207626
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PMID:
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27470486
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Background: There are limited data concerning the incidence density (ID) of ATTRwt, AL and AA amyloidosis in the Argentinean population. Our aim was to estimate the ID of ATTRwt, AL and AA amyloidosis at the Hospital Italiano Medical Care Program in Buenos Aires, Argentina.
Methods: Population was all members of a hospital-based health maintenance organization who were affiliated since January 2006 to December 2014. Each person was followed contributing time at risk since January 2006 or enrollment date to the final date. Incident cases of amyloidosis were captured from the institutional registry of amyloidosis. Incidence rate was calculated with 95% confidence intervals.
Results: During the nine-year study period, there were 15 patients with ATTRwt, 12 with AL and 2 with AA amyloidosis for 1 105 152 person-years of follow-up. The crude ID of ATTRwt amyloidosis was 13.5 (95%CI 8.1-22.4), that of AL amyloidosis 11 (95%CI: 6-19) and that of AA amyloidosis 1.8 (95%CI: 0.5-7.2) per 1 000 000 person-years. The highest ID was found in men (31.7 for ATTRwt, 15.9 for AL and 2.27 for AA amyloidosis per 1 000 000 person-years). The ID adjusted to the population of the city of Buenos Aires was 6.46 (95%CI: 3.17-9.74) for ATTRwt, 6.13 (95%CI: 2.57-9.7) for AL and 1.21 (95%CI: 0.56 to 2.99) for AA amyloidosis.
Conclusions: This is the first paper to report the incidence density of ATTRwt, AL and AA amyloidosis in Latin America. Our results are consistent with other studies from other regions. Although systemic amyloidosis is a rare disease, it is a major health problem because of its morbi-mortality.
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