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Tytuł pozycji:

The prognostic value of serum signal peptide-Cub-Egf domain-containing protein-1 concentrations in acute intracerebral hemorrhage.

Tytuł:
The prognostic value of serum signal peptide-Cub-Egf domain-containing protein-1 concentrations in acute intracerebral hemorrhage.
Autorzy:
Qiu SZ; Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
Wang HX; Department of Neurology, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
Shen J; Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
Zheng GR; Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China. Electronic address: .
Chen B; Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
Huang JJ; Department of Neurosurgery, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
Gao JB; Department of Emergency Medicine, The First People's Hospital of Fuyang District of Hangzhou City, 429 Beihuan Road, Fuyang District, Hangzhou 311400, China.
Źródło:
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2016 Oct 01; Vol. 461, pp. 103-9. Date of Electronic Publication: 2016 Aug 02.
Typ publikacji:
Journal Article; Observational Study
Język:
English
Imprint Name(s):
Original Publication: Amsterdam, Elsevier.
MeSH Terms:
Cerebral Hemorrhage/*blood
Membrane Proteins/*blood
Acute Disease ; Aged ; Aged, 80 and over ; Calcium-Binding Proteins ; Cerebral Hemorrhage/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Prospective Studies
Contributed Indexing:
Keywords: Biomarker; Intracerebral hemorrhage; Prognosis; Severity; Signal peptide-Cub-Epidermal growth factor domain-containing protein 1
Substance Nomenclature:
0 (Calcium-Binding Proteins)
0 (Membrane Proteins)
0 (SCUBE1 protein, human)
Entry Date(s):
Date Created: 20160807 Date Completed: 20170206 Latest Revision: 20201209
Update Code:
20240104
DOI:
10.1016/j.cca.2016.08.001
PMID:
27496080
Czasopismo naukowe
Background: Signal peptide-Cub-Epidermal growth factor domain-containing protein 1 (SCUBE1) in peripheral blood, which is identified as a marker for coagulation, was reported to be an independent predictor of poor outcome in some illnesses. We investigated the clinical utility of serum SCUBE1 in the prognosis of intracerebral hemorrhage (ICH).
Methods: A total of 128 consecutive patients, admitted to emergency service due to acute ICH, and 128 healthy individuals were included in this prospective study. The patients were followed up until 6months or death. An unfavorable outcome was defined as modified Rankin Scale score>2.
Results: Serum SCUBE1 concentration was markedly higher in patients than in controls and was associated with hematoma volume, National Institutes of Health Stroke Scale (NIHSS) score and blood platelet count. After adjustment for hematoma volume and NIHSS score, it was still related to early neurological deterioration, hematoma growth, 1-week mortality, 6-month mortality, 6-month unfavorable outcome and 6-month overall survival. Additionally, serum SCUBE1 significantly improved areas under receiver operating characteristic curve of hematoma volume and NIHSS score to predict 6-month unfavorable outcome.
Conclusions: Increased serum SCUBE1 concentrations have close relation to increasing severity and poor prognosis of ICH.
(Copyright © 2016 Elsevier B.V. All rights reserved.)

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