Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Chemometric aided NIR portable instrument for rapid assessment of medicine quality.

Tytuł :
Chemometric aided NIR portable instrument for rapid assessment of medicine quality.
Autorzy :
Zontov YV; National Research University Higher School of Economics (HSE), Myasnitskaya Str. 20, 101000 Moscow, Russia. Electronic address: .
Balyklova KS; I.M. Sechenov First Moscow State Medical University, Trubetskaya Str. 8. b.2, 119991 Moscow, Russia.
Titova AV; Pirogov Russian National Research Medical University, Ostrovityanova Str. 1, 117997 Moscow, Russia.
Rodionova OY; N.N. Semenov Institute of Chemical Physics RAS, Kosygin 4, 119991 Moscow, Russia.
Pomerantsev AL; N.N. Semenov Institute of Chemical Physics RAS, Kosygin 4, 119991 Moscow, Russia.
Pokaż więcej
Źródło :
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2016 Nov 30; Vol. 131, pp. 87-93. Date of Electronic Publication: 2016 Aug 07.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: <2006->: London : Elsevier Science
Original Publication: Oxford ; New York : Pergamon Press, c1983-
MeSH Terms :
Mobile Applications*
Counterfeit Drugs/*analysis
Pharmaceutical Preparations/*analysis
Pharmaceutical Preparations/*standards
Spectroscopy, Near-Infrared/*methods
Spectroscopy, Near-Infrared/instrumentation ; Time Factors
Contributed Indexing :
Keywords: Counterfeit drug detection*; Data driven soft independent modeling of class analogy*; Handheld near-infrared spectrometer*
Substance Nomenclature :
0 (Counterfeit Drugs)
0 (Pharmaceutical Preparations)
Entry Date(s) :
Date Created: 20160821 Date Completed: 20170512 Latest Revision: 20171008
Update Code :
20210623
DOI :
10.1016/j.jpba.2016.08.008
PMID :
27543912
Czasopismo naukowe
The progress in instrumentation technology has led to miniaturization of NIR instruments. Fast systems that contain no moving parts were developed to be used in the field, warehouses, drugstores, etc. At the same time, in general these portable/handheld spectrometers have a lower spectral resolution and a narrower spectral region than stationary ones. Vendors of portable instruments supply their equipment with special software for spectra processing, which aims at simplifying the analyst's work to the highest degree possible. Often such software is not fully capable of solving complex problems. In application to a real-world problem of counterfeit drug detection we demonstrate that even impaired spectral data do carry information sufficient for drug authentication. The chemometrics aided approach helps to extract this information and thus to extend the applicability of miniaturized NIR instruments. MicroPhazir-RX NIR spectrometer is used as an example of a portable instrument. The data driven soft independent modeling of class analogy (DD-SIMCA) method is employed for data processing. A representative set of tablets of a calcium channel blocker from 6 different manufacturers is used to illustrate the proposed approach. It is shown that the DD-SIMCA approach yields a better result than the basic method provided by the instrument vendor.
(Copyright © 2016 Elsevier B.V. All rights reserved.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies