Gamma-Ray Treatment of Echinococcus Protoscoleces prior to Implantation in Mice Reduces Echinococcosis.

Szczegóły
Abstrakt

Tytuł:: Gamma-Ray Treatment of Echinococcus Protoscoleces prior to Implantation in Mice Reduces Echinococcosis.
Autorzy:: Yuan Q; Department of General Surgery, Ya'an People's Hospital, Ya'an, China.
Li B; Hepatobiliary Surgery, The Affiliated Hospital of Luzhou Medical College, Luzhou, China.
Jiang S; Department of General Surgery, Ya'an People's Hospital, Ya'an, China.
Zhao Q; Department of General Surgery, Ya'an People's Hospital, Ya'an, China.
Duo J; Ganzi State Hospital, Kangding, China.
Huang X; Ganzi State Hospital, Kangding, China.
Źródło:: BioMed research international [Biomed Res Int] 2016; Vol. 2016, pp. 9027489. Date of Electronic Publication: 2016 Aug 16.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: New York, NY : Hindawi Pub. Co.
MeSH Terms:: Echinococcus*
Echinococcosis/*radiotherapy
Gamma Rays/*therapeutic use
Animals ; Female ; Mice
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Entry Date(s):: Date Created: 20160910 Date Completed: 20170210 Latest Revision: 20181113
Update Code:: 20240104
PubMed Central ID:: PMC5004023
DOI:: 10.1155/2016/9027489
PMID:: 27610384
: Czasopismo naukowe

Pełny tekst

Echinococcosis is a serious parasitic disease caused by Echinococcus tapeworms. Protoscoleces are sometimes released during surgical treatment for hydatid cysts, causing the recurrence of echinococcosis. Protoscoleces may be susceptible to radiation therapy. In this study Echinococcus protoscoleces were cultured in vitro and then divided into four different γ-ray irradiation dose groups (10 Gy, 20 Gy, 40 Gy, and 80 Gy) and a blank group. The protoscoleces were then implanted into the abdominal cavity of mice. Four months later, we observed that the incidence and weight of cysts declined with the increase of irradiation dose. γ-ray irradiation can suppress the generation of Echinococcus originated from protoscolex, the reason of which is due to the damaging to the structure of Echinococcus. Irradiation may prevent echinococcosis recurrence after surgical removal of hydatid cysts.

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