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Tytuł pozycji:

Exposure to silicon carbide and cancer risk: a systematic review.

Exposure to silicon carbide and cancer risk: a systematic review.
Boffetta P; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
Hashim D; Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
International archives of occupational and environmental health [Int Arch Occup Environ Health] 2017 Jan; Vol. 90 (1), pp. 1-12. Date of Electronic Publication: 2016 Sep 14.
Typ publikacji:
Journal Article; Meta-Analysis; Review; Systematic Review
Imprint Name(s):
Original Publication: Berlin, New York : Springer-Verlag.
MeSH Terms:
Manufacturing Industry*
Carbon Compounds, Inorganic/*toxicity
Lung Neoplasms/*chemically induced
Occupational Diseases/*chemically induced
Occupational Exposure/*adverse effects
Silicon Compounds/*toxicity
Dust ; Humans ; Risk Factors ; Silicon Dioxide/toxicity
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Contributed Indexing:
Keywords: Carborundum; Dust/adverse effects; Lung neoplasms; Neoplasms; Occupational disease; Silicon carbide; Silicon/adverse effects
Substance Nomenclature:
0 (Carbon Compounds, Inorganic)
0 (Dust)
0 (Silicon Compounds)
7631-86-9 (Silicon Dioxide)
WXQ6E537EW (silicon carbide)
Entry Date(s):
Date Created: 20160916 Date Completed: 20170718 Latest Revision: 20181202
Update Code:
Czasopismo naukowe
Purpose: To conduct a systematic review of epidemiologic studies on risk of cancer from exposure to silicon carbide (SiC).
Methods: We followed established guidelines to search electronic databases for studies on populations exposed to SiC. We conducted meta-analyses when the data justified it.
Results: We identified two studies of SiC production workers and several studies of users. The studies of production workers indicated an increased risk of lung cancer. The increased risk was restricted to workers with elevated dust exposure and, in the most informative study from Norway, was linked to estimated cristobalite exposure, a form of crystalline silica. Increased risk was not linked to SiC particles, once cristobalite exposure was controlled for. Studies of SiC users in various industries did not reveal an increased risk of lung cancer.
Conclusions: The increased risk of lung cancer detected in the SiC production industry appears to be associated with high exposure levels to total dust, including crystalline silica and cristobalite which occurred in this industry in the past decades. It may not persist under current exposure circumstances, characterized by lower levels and use of personal protection equipment. Commercial users of SiC-based products were not affected.

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