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Tytuł:
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Within- and Across-Sex Inheritance of Bone Microarchitecture.
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Autorzy:
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Pepe J; Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.; Department of Internal Medicine and Medical Disciplines, 'Sapienza' University of Rome, Rome, 00161, Italy; and.
Biver E; Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.
Bonnet N; Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.
Herrmann FR; Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.; Division of Geriatrics, Department of Internal Medicine, Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Rizzoli R; Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.
Chevalley T; Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.
Ferrari SL; Division of Bone Diseases, University Hospitals and Faculty of Medicine, CH-1205, Geneva, Switzerland.
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Źródło:
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The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2017 Jan 01; Vol. 102 (1), pp. 40-45.
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Typ publikacji:
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Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2017- : New York : Oxford University Press
Original Publication: Springfield, Ill. : Charles C. Thomas
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MeSH Terms:
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Inheritance Patterns*
Bone Density/*physiology
Bone and Bones/*physiology
Absorptiometry, Photon/methods ; Adult ; Bone and Bones/diagnostic imaging ; Child ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Mothers ; Nuclear Family ; Prognosis ; Sex Characteristics ; Tomography, X-Ray Computed/methods ; Young Adult
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Entry Date(s):
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Date Created: 20161013 Date Completed: 20170620 Latest Revision: 20180509
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Update Code:
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20240104
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DOI:
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10.1210/jc.2016-2804
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PMID:
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27732327
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Context: The maternal heritability of bone microarchitecture according to the sex of the offspring is not known.
Objective: To explore sex difference and influence of mother's menopausal status on the heritability of bone microarchitecture between mothers and their offspring.
Subjects and Methods: In 102 mother-daughter and 161 mother-son pairs, volumetric bone mineral density (BMD) and bone microarchitecture were measured at the distal radius and tibia by high-resolution peripheral quantitative computed tomography. A principal components analysis was applied for the radius and the tibia volumetric BMD and microarchitecture parameters separately. Two components, a trabecular one and a cortical one were identified at the radius and tibia. Half heritability (½h2) was estimated as the slope of the regression between offspring and mothers for each bone parameter separately.
Results: The mean age (± standard deviation) of mothers and daughters was 50.6 ± 4.1 years and 20.4 ± 0.5 years, respectively; that of mothers and sons was 45.8 ± 3.9 years and 15.2 ± 0.5 years, respectively. Most trabecular and cortical parameters were inherited in both mother-daughter and mother-son pairs (β = 0.15 to 0.33; P = 0.05 to 0.001). At the tibia, trabecular and cortical principal components were significantly inherited in both sexes, whereas only the trabecular one was inherited at the radius (½h2, 21% to 35%). There was no difference in heritability of bone microarchitecture between mother-daughter and mother-son pairs. All heritabilities remained after adjustment for age, weight, height, gonadal status, and areal BMD (½h2, 9% to 25%). In the mother-daughter pairs, there was no systematic drop of heritability across menopause.
Conclusions: Volumetric bone density and microarchitecture are highly and similarly inherited between and within sexes. The genetic effects remain predominant across menopause.
(Copyright © 2017 by the Endocrine Society)
