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Tytuł pozycji:

Manipulation of Ovarian Function Significantly Influenced Sarcopenia in Postreproductive-Age Mice.

Tytuł:
Manipulation of Ovarian Function Significantly Influenced Sarcopenia in Postreproductive-Age Mice.
Autorzy:
Peterson RL; Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, Logan, UT, USA.
Parkinson KC; Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, Logan, UT, USA.
Mason JB; Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, Logan, UT, USA.
Źródło:
Journal of transplantation [J Transplant] 2016; Vol. 2016, pp. 4570842. Date of Electronic Publication: 2016 Sep 22.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: [New York, NY] : Hindawi Pub. Corp.
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Entry Date(s):
Date Created: 20161018 Latest Revision: 20200930
Update Code:
20220902
PubMed Central ID:
PMC5055969
DOI:
10.1155/2016/4570842
PMID:
27747096
Czasopismo naukowe
Previously, transplantation of ovaries from young cycling mice into old postreproductive-age mice increased life span. We anticipated that the same factors that increased life span could also influence health span. Female CBA/J mice received new (60 d) ovaries at 12 and 17 months of age and were evaluated at 16 and 25 months of age, respectively. There were no significant differences in body weight among any age or treatment group. The percentage of fat mass was significantly increased at 13 and 16 months of age but was reduced by ovarian transplantation in 16-month-old mice. The percentages of lean body mass and total body water were significantly reduced in 13-month-old control mice but were restored in 16- and 25-month-old recipient mice by ovarian transplantation to the levels found in six-month-old control mice. In summary, we have shown that skeletal muscle mass, which is negatively influenced by aging, can be positively influenced or restored by reestablishment of active ovarian function in aged female mice. These findings provide strong incentive for further investigation of the positive influence of young ovaries on restoration of health in postreproductive females.
Competing Interests: All authors declare that there are no competing interests.

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