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Tytuł:
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[Cord blood procalcitonin in the assessment of early-onset neonatal sepsis].
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Autorzy:
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Oria de Rueda Salguero O; Unidad de Neonatología, Servicio de Pediatría, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España. Electronic address: .
Beceiro Mosquera J; Unidad de Neonatología, Servicio de Pediatría, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
Barrionuevo González M; Unidad de Neonatología, Servicio de Pediatría, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
Ripalda Crespo MJ; Unidad de Neonatología, Servicio de Pediatría, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
Olivas López de Soria C; Unidad de Neonatología, Servicio de Pediatría, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
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Transliterated Title:
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Procalcitonina en sangre de cordón en la valoración del riesgo de sepsis neonatal precoz.
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Źródło:
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Anales de pediatria (Barcelona, Spain : 2003) [An Pediatr (Barc)] 2017 Aug; Vol. 87 (2), pp. 87-94. Date of Electronic Publication: 2016 Oct 14.
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Typ publikacji:
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Journal Article
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Język:
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Spanish; Castilian
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Imprint Name(s):
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Publication: Madrid : Elsevier España
Original Publication: Barcelona : Ediciones Doyma, SL, c2003-
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MeSH Terms:
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Fetal Blood*
Neonatal Sepsis/*blood
Neonatal Sepsis/*diagnosis
Procalcitonin/*blood
Clinical Protocols ; Humans ; Infant, Newborn ; Retrospective Studies ; Risk Assessment
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Contributed Indexing:
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Keywords: Chorioamnionitis; Cord blood; Corioamnionitis; Diagnóstico de sepsis; Early onset neonatal sepsis; Inflamatory markers; Marcadores inflamatorios; Neonatal infection risk; Newborn; Procalcitonin; Procalcitonina; Recién nacido; Riesgo infeccioso neonatal; Sangre de cordón; Sepsis diagnosis; Sepsis neonatal precoz
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Substance Nomenclature:
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0 (Procalcitonin)
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Entry Date(s):
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Date Created: 20161019 Date Completed: 20190104 Latest Revision: 20190104
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Update Code:
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20240104
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DOI:
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10.1016/j.anpedi.2016.09.003
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PMID:
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27751752
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Introduction: Early diagnosis of early-onset neonatal sepsis (EONS) is essential to reduce morbidity and mortality. Procalcitonin (PCT) in cord blood could provide a diagnosis of infected patients from birth.
Objective: To study the usefulness and safety of a procedure for the evaluation of newborns at risk of EONS, based on the determination of PCT in cord blood.
Patients and Methods: Neonates with infectious risk factors, born in our hospital from October 2013 to January 2015 were included. They were processed according to an algorithm based on the values of cord blood procalcitonin (< 0.6ng/ml versus ≥0.6ng/ml). They were later classified as proved infection, probable, or no infection.
Results and Conclusions: Of the 2,519 infants born in the study period, 136 met inclusion criteria. None of 120 cases with PCT<0.6ng/ml in cord blood developed EONS (100% negative predictive value). On the other hand, of the 16 cases with PCT ≥0.6ng/ml, 10 were proven or probably infected (62.5% positive predictive value). The sensitivity of the PCT against infection was 100%, with a specificity of 95.2% (area under the receiver operator curve 0.969). The incidence of infection in the study group was 7.4%, and 26.1% in cases with maternal chorioamnionitis. 21 newborn (15.4%) received antibiotic therapy. The studied protocol has shown to be effective and safe to differentiate between patients with increased risk of developing an EONS, in those where the diagnostic and therapeutic approach was more interventionist, versus those with less likelihood of sepsis, who would benefit from a more conservative management.
(Copyright © 2016 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.)
