Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R.

Szczegóły
Abstrakt

Tytuł:: Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R.
Autorzy:: Kojima T; Department of Immune Regulation, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Tsuchiya K; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences. Tokyo 113-8519, Japan.
Ikemizu S; Division of Structural Biology, Graduate School of Pharmaceutical Sciences, Kumamoto University. Kumamoto 862-0973, Japan.
Yoshikawa S; Department of Immune Regulation, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Yamanishi Y; Department of Immune Regulation, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Watanabe M; Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences. Tokyo 113-8519, Japan.
Karasuyama H; Department of Immune Regulation, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Źródło:: Scientific reports [Sci Rep] 2016 Nov 07; Vol. 6, pp. 36457. Date of Electronic Publication: 2016 Nov 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Ligands*
Antigens, CD/*metabolism
Membrane Glycoproteins/*metabolism
Amino Acid Sequence ; Animals ; Antigens, CD/chemistry ; Cell Line, Tumor ; Cell Lineage ; Cytokines/metabolism ; Epithelial Cells/metabolism ; Gastrointestinal Tract/cytology ; Gastrointestinal Tract/metabolism ; Genetic Vectors/genetics ; Genetic Vectors/metabolism ; Lymphocytes/cytology ; Lymphocytes/metabolism ; Membrane Glycoproteins/chemistry ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; NIH 3T3 Cells ; Protein Binding ; Rats ; Rats, Sprague-Dawley ; Sequence Alignment ; Sequence Homology, Amino Acid
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Substance Nomenclature:: 0 (Antigens, CD)
0 (CD200 receptor, mouse)
0 (Cytokines)
0 (Ligands)
0 (Membrane Glycoproteins)
UQ4V77A8VA (antigens, CD200)
Entry Date(s):: Date Created: 20161108 Date Completed: 20180710 Latest Revision: 20181202
Update Code:: 20240105
PubMed Central ID:: PMC5098219
DOI:: 10.1038/srep36457
PMID:: 27819346
: Czasopismo naukowe

Pełny tekst

CD200R is an inhibitory receptor expressed on myeloid cells and some lymphoid cells, and plays important roles in negatively regulating immune responses. CD200 is the only known ligand of CD200R and broadly distributed in a variety of cell types. Here we identified novel CD200 homologues, designated iSEC1 and iSEC2, that are expressed exclusively by secretory cell lineages in the gastrointestinal epithelium while authentic CD200 is expressed by none of epithelial cells including secretory cells. Both iSEC1 and iSEC2 could bind to CD200R but not other members of the CD200R family. Notably, CD200R expression was confined to intraepithelial lymphocytes (IELs) among cells in the gastrointestinal epithelium. Binding of iSEC1 to CD200R on IELs resulted in the suppression of cytokine production and cytolytic activity by activated IELs. Thus, iSEC1 is a previously unappreciated CD200R ligand with restricted expression in gastrointestinal secretory cells and may negatively regulate mucosal immune responses.

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