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Tytuł:
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Immune responses in perinatal brain injury.
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Autorzy:
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Lai JCY; Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden.
Rocha-Ferreira E; Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden.
Ek CJ; Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden.
Wang X; Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden.
Hagberg H; Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden.
Mallard C; Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 432, 405 30 Gothenburg, Sweden. Electronic address: .
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Źródło:
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Brain, behavior, and immunity [Brain Behav Immun] 2017 Jul; Vol. 63, pp. 210-223. Date of Electronic Publication: 2016 Nov 16.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Publication: <2000- > : Amsterdam : Elsevier
Original Publication: San Diego : Academic Press, [c1987-
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MeSH Terms:
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Brain/*immunology
Hypoxia-Ischemia, Brain/*immunology
Immunity, Maternally-Acquired/*immunology
Animals ; Animals, Newborn ; Brain Injuries/immunology ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Rodentia
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Grant Information:
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G0802853 United Kingdom MRC_ Medical Research Council
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Contributed Indexing:
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Keywords: Brain injury; Hypoxia-ischemia; Inflammation; Neonatal; Peripheral immune
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Entry Date(s):
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Date Created: 20161121 Date Completed: 20180130 Latest Revision: 20220129
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Update Code:
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20240105
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DOI:
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10.1016/j.bbi.2016.10.022
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PMID:
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27865947
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The perinatal period has often been described as immune deficient. However, it has become clear that immune responses in the neonate following exposure to microbes or as a result of tissue injury may be substantial and play a role in perinatal brain injury. In this article we will review the immune cell composition under normal physiological conditions in the perinatal period, both in the human and rodent. We will summarize evidence of the inflammatory responses to stimuli and discuss how neonatal immune activation, both in the central nervous system and in the periphery, may contribute to perinatal hypoxic-ischemic brain injury.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
