-
Tytuł:
-
Effect of preceding medications on resuscitation outcome of out-of-hospital cardiac arrest.
-
Autorzy:
-
Hung SW; Department of Emergency, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.; School of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
Chu CM; Department of Emergency, Hsinchu Cathay General Hospital, Hsinchu City, Taiwan.
Su CF; Department of Emergency, Hsinchu Cathay General Hospital, Hsinchu City, Taiwan.
Tseng LM; Department of Emergency, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Wang TL; Department of Emergency, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.; School of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
-
Źródło:
-
Journal of investigative medicine : the official publication of the American Federation for Clinical Research [J Investig Med] 2017 Mar; Vol. 65 (3), pp. 689-693. Date of Electronic Publication: 2016 Dec 13.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Publication: 2023-: [Thousand Oaks] : SAGE Publications
Original Publication: Thorofare, NJ : Slack, c1994-
-
MeSH Terms:
-
Out-of-Hospital Cardiac Arrest*
Premedication*
Resuscitation*
Aged ; Female ; Humans ; Logistic Models ; Male ; Multivariate Analysis ; Survival Analysis ; Treatment Outcome
-
References:
-
Am J Cardiol. 1997 Apr 1;79(7):909-13. (PMID: 9104905)
Circulation. 2000 Aug 8;102(6):649-54. (PMID: 10931805)
Cardiology. 2005;104(4):210-4. (PMID: 16155396)
Resuscitation. 2010 Nov;81(11):1479-87. (PMID: 20828914)
Prog Cardiovasc Dis. 1994 Jul-Aug;37(1):39-48. (PMID: 8022985)
Heart Rhythm. 2013 Aug;10(8):1153-8. (PMID: 23680897)
Am J Cardiovasc Drugs. 2010;10(3):155-64. (PMID: 20524717)
Ann Intern Med. 2004 Dec 7;141(11):829-34. (PMID: 15583223)
J Am Coll Cardiol. 1999 Jan;33(1):46-52. (PMID: 9935007)
Kaohsiung J Med Sci. 2007 May;23(5):217-24. (PMID: 17525003)
Resuscitation. 2015 Nov;96:328-40. (PMID: 25438254)
Circulation. 2004 Jun 15;109(23 Suppl 1):III39-43. (PMID: 15198965)
Eur Heart J. 2015 Nov 1;36(41):2793-867. (PMID: 26320108)
Circulation. 1992 Jan;85(1 Suppl):I2-10. (PMID: 1728501)
Eur Heart J. 2012 Jul;33(13):1571-81. (PMID: 22307462)
Emerg Med J. 2004 Jan;21(1):95-8. (PMID: 14734394)
Am J Med. 2015 Dec;128(12):1272-4. (PMID: 26159635)
-
Contributed Indexing:
-
Keywords: Arrhythmias, Cardiac; Emergency Service, Hospital; Heart Arrest; Medicine
-
Entry Date(s):
-
Date Created: 20161215 Date Completed: 20171218 Latest Revision: 20181113
-
Update Code:
-
20240105
-
PubMed Central ID:
-
PMC5339563
-
DOI:
-
10.1136/jim-2016-000264
-
PMID:
-
27965361
-
As evidence regarding the impact of preceding medications on resuscitation outcomes has been inconsistent, this study aimed to analyze the association between preceding medications and resuscitation outcomes in patients experiencing out-of-hospital cardiac arrest (OHCA). This retrospective study included patients with OHCA presenting to a tertiary care hospital by emergency medical service (EMS) between January 2006 and June 2011. Using the Utstein template, data were collected from EMS and hospital medical records for prehospital care, in-hospital care, and medications which were taken continuously for at least 2 weeks preceding OHCA. Primary outcome was the proportion of patients with a survived event. Multivariable logistic regression analyses were performed to evaluate the predictors of survived events. Among the 1381 included patients with OHCA, 552 (40.0%) patients achieved sustained return of spontaneous circulation and 463 (33.5%) patients survived after resuscitation, 96 (7.0%) patients survived until discharge, and 20 (1.4%) patients had a favorable neurological outcome at discharge. The multivariable analyses revealed that use of statins preceding OHCA was independently associated with a greater probability of a survived events (OR=2.09, 95% CI 1.08 to 4.03, p=0.028).Use of digoxin was adversely associated with survived events (OR=0.39, 95% CI 0.16 to 0.90, p=0.028) in patients with OHCA. The continuous use of statins preceding OHCA was positively associated with survived events, while use of digoxin was adversely related. It deserves more attention on medications preceding OHCA because of their potential effect on resuscitation outcomes.
(Copyright © 2017 American Federation for Medical Research.)
Comment in: J Investig Med. 2017 Oct;65(7):e4. (PMID: 28824004)
