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Tytuł pozycji:

Novel androgen-induced activity of an antimicrobial β-defensin: Regulation of Wolffian duct morphogenesis.

Tytuł :
Novel androgen-induced activity of an antimicrobial β-defensin: Regulation of Wolffian duct morphogenesis.
Autorzy :
Ribeiro CM; Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil.
Ferreira LG; Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil.
Thimoteo DS; Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil.
Smith LB; MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK.
Hinton BT; Department of Cell Biology, University of Virginia, School of Medicine, Charlottesville, VA, USA.
Avellar MC; Section of Experimental Endocrinology, Department of Pharmacology, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brazil. Electronic address: .
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Źródło :
Molecular and cellular endocrinology [Mol Cell Endocrinol] 2017 Feb 15; Vol. 442, pp. 142-152. Date of Electronic Publication: 2016 Dec 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: Limerick : North Holland Publishing
Original Publication: Amsterdam, North-Holland.
MeSH Terms :
Androgens/*pharmacology
Anti-Infective Agents/*pharmacology
Morphogenesis/*drug effects
Wolffian Ducts/*drug effects
beta-Defensins/*pharmacology
Animals ; Antigens, Surface/metabolism ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Epididymis/drug effects ; Epididymis/metabolism ; Epithelium/drug effects ; Epithelium/metabolism ; Female ; Gene Expression Regulation, Developmental/drug effects ; Humans ; Male ; Mice ; Mice, Knockout ; Organogenesis/drug effects ; Rats ; Rats, Wistar ; Receptors, Androgen/metabolism ; Wolffian Ducts/metabolism
Grant Information :
R01 HD069654 United States HD NICHD NIH HHS; MR/N002970/1 United Kingdom Medical Research Council
Contributed Indexing :
Keywords: Androgen*; Epididymis*; Innate immunity*; Male infertility*; Wolffian duct*; β-defensin*
Substance Nomenclature :
0 (Androgens)
0 (Anti-Infective Agents)
0 (Antigens, Surface)
0 (Receptors, Androgen)
0 (beta-Defensins)
Entry Date(s) :
Date Created: 20161220 Date Completed: 20171030 Latest Revision: 20180907
Update Code :
20210210
DOI :
10.1016/j.mce.2016.12.016
PMID :
27989506
Czasopismo naukowe
The Wolffian duct (WD) undergoes morphological changes induced by androgens to form the epididymis, which is an organ essential for sperm maturation. Androgen action in WD epithelium involves paracrine factors of mesenchymal origin that function by still poorly understood mechanisms. Here we studied the antimicrobial β-defensin SPAG11C as a new player in duct morphogenesis, localized prenatally in the WD mesenchyme. Organotypic culture of rat WDs and tissues from Androgen Receptor (AR) knockout mice (ARKO) were used. Our results show that androgen/AR signaling differentially regulated SPAG11C expression at mRNA and protein levels in the developing WD. WDs incubated with recombinant human SPAG11C were shorter and less coiled as a result of reduced epithelial cell proliferation, but not increased apoptosis. Our results suggested β-defensin SPAG11C as an androgen-target required for WD morphogenesis. This highlights the multifunctional repertoire of the β-defensin protein family and their potential contribution to the in utero environment that determines male reproductive success.
(Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

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