Identification of novel candidate genes for the inverted teat defect in sows using a genome-wide marker panel.

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Tytuł:: Identification of novel candidate genes for the inverted teat defect in sows using a genome-wide marker panel.
Autorzy:: Chalkias H; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, SE-750 07, Uppsala, Sweden.
Jonas E; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, SE-750 07, Uppsala, Sweden. .
Andersson LS; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, SE-750 07, Uppsala, Sweden.
Jacobson M; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7054, SE-750 07, Uppsala, Sweden.
de Koning DJ; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, SE-750 07, Uppsala, Sweden.
Lundeheim N; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, SE-750 07, Uppsala, Sweden.
Lindgren G; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, SE-750 07, Uppsala, Sweden.; Capilet Genetics AB, SE-725 93, Västerås, Sweden.
Źródło:: Journal of applied genetics [J Appl Genet] 2017 May; Vol. 58 (2), pp. 249-259. Date of Electronic Publication: 2017 Jan 04.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: 2011- : Cheshire, United Kingdom : Springer
Original Publication: Poznań, Poland : Institute of Plant Genetics, Polish Academy of Sciences, 1995-
MeSH Terms:: Genome-Wide Association Study/*veterinary
Mammary Glands, Animal/*abnormalities
Sus scrofa/*genetics
Animals ; Breeding ; Female ; Genetic Markers ; Genotype ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; X Chromosome
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Contributed Indexing:: Keywords: Functional teats; Genetic markers; Genome-wide association study; SNP; Teat number; Yorkshire breed
Substance Nomenclature:: 0 (Genetic Markers)
Entry Date(s):: Date Created: 20170105 Date Completed: 20170605 Latest Revision: 20181113
Update Code:: 20240104
PubMed Central ID:: PMC5391382
DOI:: 10.1007/s13353-016-0382-1
PMID:: 28050760
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The number of functional teats is an important selection criterion in pig breeding. Inherited defects of the udder, such as the inverted teat, do have a considerable negative impact on the nursing ability of the sow. To investigate the genetic background of this defect and the number of functional teats in Swedish maternal lines, samples from 230 Yorkshire pigs were selected for genotyping using the PorcineSNP60K BeadChip (Illumina Inc.), each pig with at least one inverted teat was matched with one non-affected pig (fullsib or pairs with matching herd and gender). A genome-wide association study on these 230 pigs was performed using the two-step approach implemented in GenABEL using 46,652 single nucleotide polymorphisms across all autosomes and the X chromosome. A number of significant regions were identified for the inverted teat defect on chromosomes 2, 10, and 18. Many of the regions associated with the number of functional teats were located in the same or close regions, except two associated markers on the X chromosome and one on chromosome 3. We identified some of the regions on chromosomes previously reported in one linkage and one gene expression study. We conclude, despite being able to suggest new candidate genes, that further studies are needed to better understand the biologic background of the teat development. Despite the in-depth comparison of identified regions for the inverted teat defect done here, more studies are required to allow a clear identification of genetic regions relevant for this defect across many pig populations.

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