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Tytuł:
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An Unexpected Fatal CCHF Case and Management of Exposed Health Care Workers.
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Autorzy:
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Guven G; Ankara University Faculty of Medicine, Intensive Care Unit (Internal Medicine), Ankara, Turkey. Electronic address: .
Talan L; Ankara University Faculty of Medicine, Intensive Care Unit (Internal Medicine), Ankara, Turkey. Electronic address: .
Altintas ND; Ankara University Faculty of Medicine, Intensive Care Unit (Internal Medicine), Ankara, Turkey. Electronic address: .
Memikoglu KO; Ankara University Faculty of Medicine, Department of Infectious Disease and Clinical Microbiology, Ankara, Turkey. Electronic address: .
Yoruk F; Ankara University Faculty of Medicine, Department of Infectious Disease and Clinical Microbiology, Ankara, Turkey. Electronic address: .
Azap A; Ankara University Faculty of Medicine, Department of Infectious Disease and Clinical Microbiology, Ankara, Turkey. Electronic address: .
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Źródło:
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2017 Feb; Vol. 55, pp. 118-121. Date of Electronic Publication: 2017 Jan 06.
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Typ publikacji:
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Case Reports; Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Hamilton, ON : Elsevier
Original Publication: Hamilton, ON : Decker, c1996-
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MeSH Terms:
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Health Personnel*
Occupational Exposure*
Hemorrhagic Fever, Crimean/*etiology
Hemorrhagic Fever, Crimean/*mortality
Adult ; Antiviral Agents/therapeutic use ; Child, Preschool ; Female ; Hemorrhagic Fever Virus, Crimean-Congo ; Hemorrhagic Fever, Crimean/drug therapy ; Humans ; Male ; Middle Aged ; Ribavirin/therapeutic use
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Contributed Indexing:
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Keywords: Crimean-Congo Hemorrhagic Fever; health care workers; prophylaxis; ribavirin
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Substance Nomenclature:
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0 (Antiviral Agents)
49717AWG6K (Ribavirin)
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Entry Date(s):
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Date Created: 20170111 Date Completed: 20170419 Latest Revision: 20220409
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Update Code:
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20240104
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DOI:
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10.1016/j.ijid.2016.12.026
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PMID:
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28069471
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Crimean-Congo hemorrhagic fever (CCHF) is a tick borne viral disease which can also be transmitted by direct contact with blood or tissue specimens of infected animals or humans. We present a fatal case of CCHF, who was diagnosed after death, and describe the post-exposure management plan for the health care workers (HCWs) involved in her care. In total of 52 HCWs were involved in the patient's care and they were stratified into risk groups. Overall, 20 HCWs were grouped in high and intermediate risk groups, including the HCW with needle stick injury. High and intermediate risk groups were offered post exposure prophlaxis (PEP) with ribavirin. Fourteen of 20 HCWs started PEP, however 10 ceased after negative CCHF-PCR results. Negative CCHF-PCR results were reported for all HCWs at the 5th day of exposure. Side effects with PEP developed in 5 of HCWs and were mainly gastrointestinal complaints which reversed after drug discontinuation. All HCWs were followed for 14 days both clinically and with laboratory tests. None of the HCWs developed CCHF. PEP with ribavirin can be considered as a safe option in protection.
(Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)
