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Tytuł:
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Method for the Determination of Carbonyl Compounds in E-Cigarette Aerosols.
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Autorzy:
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Flora JW; Altria Client Services LLC, 601 East Jackson Street, Richmond, VA 23219, USA .
Wilkinson CT; Altria Client Services LLC, 601 East Jackson Street, Richmond, VA 23219, USA.
Wilkinson JW; Altria Client Services LLC, 601 East Jackson Street, Richmond, VA 23219, USA.
Lipowicz PJ; Altria Client Services LLC, 601 East Jackson Street, Richmond, VA 23219, USA.
Skapars JA; Altria Client Services LLC, 601 East Jackson Street, Richmond, VA 23219, USA.
Anderson A; Altria Client Services LLC, 601 East Jackson Street, Richmond, VA 23219, USA.
Miller JH; Altria Client Services LLC, 601 East Jackson Street, Richmond, VA 23219, USA.
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Źródło:
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Journal of chromatographic science [J Chromatogr Sci] 2017 Feb; Vol. 55 (2), pp. 142-148. Date of Electronic Publication: 2016 Oct 07.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <2012- > : Oxford : Oxford University Press
Original Publication: Niles Il : Preston Technical Abstracts
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MeSH Terms:
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Electronic Nicotine Delivery Systems*
Aerosols/*chemistry
Aldehydes/*analysis
Gas Chromatography-Mass Spectrometry/*methods
Aerosols/analysis ; Aldehydes/chemistry ; Equipment Design ; Gas Chromatography-Mass Spectrometry/instrumentation ; Hot Temperature ; Models, Theoretical
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References:
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Substance Nomenclature:
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0 (Aerosols)
0 (Aldehydes)
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Entry Date(s):
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Date Created: 20170115 Date Completed: 20170911 Latest Revision: 20181113
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Update Code:
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20240104
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PubMed Central ID:
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PMC5253970
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DOI:
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10.1093/chromsci/bmw157
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PMID:
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28087758
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Low levels of thermal degradation products such as carbonyls (formaldehyde, acetaldehyde, acrolein, crotonaldehyde) have been reported in e-cigarette aerosols. The collection and analysis of e-cigarette aerosol carbonyls are often adapted from methods developed for tobacco cigarette smoke. These methodologies are often not sensitive enough to detect low carbonyl levels in e-cigarette aerosols. One objective of this work was to develop and validate a rapid, selective and sensitive ultra-performance liquid chromatography with mass spectrometry method optimized for analysis of carbonyls in e-cigarette aerosols. Aerosols were trapped in 20-puff collections, 4-s durations, 55-mL volumes, 30-s intervals, square wave puff profiles. Collection apparatus involved a linear smoking machine with Cambridge filter pad followed by a glass impinger containing acidified 2,4-dinitrophenylhydrazine. This method showed limits of quantitation and detection of 0.016 and 0.003 µg puff -1 , respectively, and run time of 4 min. Six e-cigarettes were evaluated (five devices each). All contained measurable levels of carbonyls. Levels were mostly well below those in conventional cigarettes. However, for some e-cigarettes, formaldehyde levels were above those for tobacco cigarettes (highest at 14.1 µg puff -1 ). Temperatures related to carbonyl yields in e-cigarette aerosols were explored to better understand carbonyl formation: formation of formaldehyde is low at temperatures below 350°C.
(© The Author 2016. Published by Oxford University Press.)