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Tytuł pozycji:

Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn's Disease Patients.

Tytuł :
Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn's Disease Patients.
Autorzy :
Ricci JER Júnior; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Chebli LA; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Ribeiro TCDR; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Castro ACS; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Gaburri PD; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Pace FHDL; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Barbosa KVBD; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Ferreira LEVVDC; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Passos MDCF; Department of Medicine, Division of Gastroenterology, Federal University of Minas Gerais, Brazil.
Malaguti C; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Delgado ÁHDA; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Campos JD; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Coelho AR; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Chebli JMF; Department of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, University Hospital of the Federal University of Juiz de Fora, University of Juiz de Fora School of Medicine.
Pokaż więcej
Źródło :
Journal of clinical gastroenterology [J Clin Gastroenterol] 2018 Jul; Vol. 52 (6), pp. 530-536.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc.
Original Publication: New York, Masson.
MeSH Terms :
Gastrointestinal Microbiome*
Blind Loop Syndrome/*epidemiology
Crohn Disease/*blood
Crohn Disease/*epidemiology
Intestine, Small/*microbiology
Adult ; Biomarkers/blood ; Blind Loop Syndrome/blood ; Blind Loop Syndrome/diagnosis ; Blind Loop Syndrome/microbiology ; Blood Sedimentation ; Brazil/epidemiology ; C-Reactive Protein/analysis ; Case-Control Studies ; Crohn Disease/diagnosis ; Crohn Disease/microbiology ; Cross-Sectional Studies ; Feces/chemistry ; Female ; Humans ; Inflammation Mediators/blood ; Leukocyte L1 Antigen Complex/analysis ; Male ; Middle Aged ; Phenotype ; Prevalence ; Prospective Studies ; Risk Assessment ; Risk Factors ; Young Adult
Substance Nomenclature :
0 (Biomarkers)
0 (Inflammation Mediators)
0 (Leukocyte L1 Antigen Complex)
9007-41-4 (C-Reactive Protein)
Entry Date(s) :
Date Created: 20170131 Date Completed: 20190930 Latest Revision: 20190930
Update Code :
20201218
DOI :
10.1097/MCG.0000000000000803
PMID :
28134633
Czasopismo naukowe
Goals: We studied the prevalence and predictors of small-intestinal bacterial overgrowth (SIBO) in Crohn's disease (CD) outpatients and the relationship between SIBO and intestinal and/or systemic inflammation.
Background: The relationship of SIBO with systemic and intestinal inflammation in CD patients is unclear.
Study: In this cross-sectional study, conducted between June, 2013 and January, 2015, 92 CD patients and 97 controls with nonchronic gastrointestinal complaints were assessed for the presence of SIBO using the H2/CH4 glucose breath test. Multivariate logistic regression was performed to investigate the potential association between SIBO and demographic, disease-related data, systemic markers of inflammation (C-reactive protein, and erythrocyte sedimentation rate), and biomarker of intestinal inflammation [fecal calprotectin concentration (FCC)].
Results: The SIBO rate was significantly higher in CD patients than in controls (32.6% vs. 12.4%, respectively, P=0.0008). Patients with and without SIBO were comparable with regard to demographics, systemic inflammatory biomarkers, and disease characteristics, except for the stricturing phenotype being more common in SIBO-positive CD patients (43.3% vs. 19.3%, P=0.015). Notably, FCC was significantly higher in SIBO-positive patients (median of 485.8 vs.132.7 μg/g; P=0.004). Patients presenting increased FCC and stricturing disease had an odds of 9.43 (95% confidence interval, 3.04-11.31; P<0.0001) and 3.83 (95% confidence interval, 1.54-6.75; P=0.025) respectively, for SIBO diagnosis.
Conclusions: In CD patients, SIBO is a highly prevalent condition. Stricturing phenotype and increased FCC were strongly and independently associated with the presence of SIBO. SIBO diagnostic work-up followed by directed treatment is recommended in CD patients who present stricturing disease, especially in those with concurrent intestinal inflammation.

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