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Tytuł:
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Coffee and tea consumption and risk of leukaemia in an adult population: A reanalysis of the Italian multicentre case-control study.
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Autorzy:
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Parodi S; Institute of Electronics, Computer and Telecommunication Engineering, National Research Council of Italy, Genoa, Italy.
Merlo DF; Unit of Clinical Trials, IRCCS San Martino-IST, Genoa, Italy.
Stagnaro E; Liguria Mortality Registry, IRCCS AOU San Martino-IST National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132 Genoa, Italy; Unit of Clinical Epidemiology, IRCCS AOU San Martino-IST National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132, Genoa, Italy. Electronic address: .
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Corporate Authors:
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Working Group for the Epidemiology of Hematolymphopoietic Malignancies in Italy
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Źródło:
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Cancer epidemiology [Cancer Epidemiol] 2017 Apr; Vol. 47, pp. 81-87. Date of Electronic Publication: 2017 Jan 30.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam : Elsevier
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MeSH Terms:
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Coffee/*adverse effects
Leukemia/*etiology
Tea/*adverse effects
Adult ; Aged ; Case-Control Studies ; Female ; Humans ; Italy/epidemiology ; Leukemia/epidemiology ; Leukemia/prevention & control ; Male ; Middle Aged ; Risk Factors ; Surveys and Questionnaires ; Young Adult
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Contributed Indexing:
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Keywords: Adult leukaemia; Case-control study; Coffee; Lymphoid malignancies; Myeloid malignancies; Tea
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Substance Nomenclature:
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0 (Coffee)
0 (Tea)
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Entry Date(s):
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Date Created: 20170204 Date Completed: 20170613 Latest Revision: 20181202
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Update Code:
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20240105
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DOI:
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10.1016/j.canep.2017.01.005
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PMID:
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28153669
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Background: Coffee and tea are the most frequently consumed beverages in the world. Their potential effect on the risk of developing different types of malignancies has been largely investigated, but studies on leukaemia in adults are scarce.
Methods: The present investigation is aimed at evaluating the potential role of regular coffee and tea intake on the risk of adult leukaemia by reanalysing a large population based case-control study carried out in Italy, a country with a high coffee consumption and a low use of green tea. Interviewed subjects, recruited between 1990 and 1993 in 11 Italian areas, included 1771 controls and 651 leukaemia cases. Association between Acute Myeloid Leukaemia (AML), Acute Lymphoid Leukaemia, Chronic Myeloid Leukaemia, Chronic Lymphoid Leukaemia, and use of coffee and tea was evaluated by standard logistic regression. Odds Ratios (OR) were estimated adjusting for the following potential confounders: gender, age, residence area, smoking habit, educational level, previous chemotherapy treatment, alcohol consumption and exposure to electromagnetic fields, radiation, pesticides and aromatic hydrocarbons.
Results: No association was observed between regular use of coffee and any type of leukaemia. A small protective effect of tea intake was found among myeloid malignancies, which was more evident among AML (OR=0.68, 95%CI: 0.49-0.94). However, no clear dose-response relation was found.
Conclusion: The lower risk of leukaemia among regular coffee consumers, reported by a few of previous small studies, was not confirmed. The protective effect of tea on the AML risk is only partly consistent with results from other investigations.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
