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Tytuł:
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Primary cerebellar lymphoma with Hodgkin lymphoma-like morphology in a cat.
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Autorzy:
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Yoshino Y; Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).; Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).; Laboratory of Veterinary Internal Medicine (Tsujimoto).; Laboratory of Veterinary Clinical Pathobiology (Matsuki).; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
Chambers JK; Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).; Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).; Laboratory of Veterinary Internal Medicine (Tsujimoto).; Laboratory of Veterinary Clinical Pathobiology (Matsuki).; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
Nakamori T; Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).; Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).; Laboratory of Veterinary Internal Medicine (Tsujimoto).; Laboratory of Veterinary Clinical Pathobiology (Matsuki).; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
Goto-Koshino Y; Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).; Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).; Laboratory of Veterinary Internal Medicine (Tsujimoto).; Laboratory of Veterinary Clinical Pathobiology (Matsuki).; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
Nishigaki K; Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).; Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).; Laboratory of Veterinary Internal Medicine (Tsujimoto).; Laboratory of Veterinary Clinical Pathobiology (Matsuki).; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
Tsujimoto H; Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).; Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).; Laboratory of Veterinary Internal Medicine (Tsujimoto).; Laboratory of Veterinary Clinical Pathobiology (Matsuki).; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
Matsuki N; Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).; Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).; Laboratory of Veterinary Internal Medicine (Tsujimoto).; Laboratory of Veterinary Clinical Pathobiology (Matsuki).; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
Nakayama H; Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).; Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).; Laboratory of Veterinary Internal Medicine (Tsujimoto).; Laboratory of Veterinary Clinical Pathobiology (Matsuki).; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
Uchida K; Laboratory of Veterinary Pathology (Yoshino, Chambers, Nakamori, Nakayama, Uchida).; Molecular Diagnostic Laboratory, Veterinary Medical Center (Goto-Koshino).; Laboratory of Veterinary Internal Medicine (Tsujimoto).; Laboratory of Veterinary Clinical Pathobiology (Matsuki).; Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; and Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan (Nishigaki).
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Źródło:
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Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc [J Vet Diagn Invest] 2017 Sep; Vol. 29 (5), pp. 707-710. Date of Electronic Publication: 2017 Apr 06.
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Typ publikacji:
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Case Reports; Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2011-: Thousand Oaks, CA : Sage
Original Publication: 1989-2004 : Columbia, MO : American Association of Veterinary Laboratory Diagnosticians
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MeSH Terms:
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Cat Diseases/*diagnosis
Hodgkin Disease/*veterinary
Leukemia Virus, Feline/*physiology
Lymphoma, B-Cell/*veterinary
Animals ; Cat Diseases/pathology ; Cat Diseases/virology ; Cats ; Hodgkin Disease/diagnosis ; Hodgkin Disease/pathology ; Hodgkin Disease/virology ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/pathology ; Lymphoma, B-Cell/virology ; Male ; Reed-Sternberg Cells/pathology
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Contributed Indexing:
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Keywords: Cats; Hodgkin-like lymphoma; cerebellum; feline leukemia virus
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Entry Date(s):
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Date Created: 20170407 Date Completed: 20180301 Latest Revision: 20220409
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Update Code:
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20240105
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DOI:
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10.1177/1040638717704239
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PMID:
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28382853
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A 4-y-old cat exhibited neurologic signs such as wobbling, right head tilt, and intention tremor, and MRI revealed a mass in the cerebellum. The cat died 5 mo after initial presentation, and no neoplastic lesions, other than the cerebellar mass, were observed at autopsy. Histologically, large atypical cells resembling Hodgkin cells, with single large inclusion-like nucleoli, and those resembling Reed-Sternberg cells, with symmetrically arranged nuclei, had infiltrated the left side of the cerebellum and were admixed with small lymphocytes. These atypical cells were positive for feline leukemia virus (FeLV), CD20, BLA36, vimentin, p16, p53, and Pax5, and negative for CD3, CD79a, and Iba1 by immunohistochemistry. Multiplex PCR for immunoglobulin heavy-chain gene rearrangement revealed monoclonal proliferation of B-lymphocytes. We describe this feline primary cerebellar B-cell lymphoma that displayed Hodgkin lymphoma-like tumor cells with FeLV protein expression.
