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Tytuł pozycji:

PROSPECTIVE EFFECT OF RED ALGAE, ACTINOTRICHIA FRAGILIS , AGAINST SOME OSTEOARTHRITIS AETIOLOGY.

Tytuł:
PROSPECTIVE EFFECT OF RED ALGAE, ACTINOTRICHIA FRAGILIS , AGAINST SOME OSTEOARTHRITIS AETIOLOGY.
Autorzy:
Sayed AA; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Sadek SA; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Solimán AM; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Marzouk M; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Źródło:
African journal of traditional, complementary, and alternative medicines : AJTCAM [Afr J Tradit Complement Altern Med] 2016 Nov 23; Vol. 14 (1), pp. 231-241. Date of Electronic Publication: 2016 Nov 23 (Print Publication: 2017).
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: 2015- : Osun : African Traditional Herbal Medicine Supporters Initiative
Original Publication: [Ile-Ife, Nigeria? : African Networks on Ethnomedicines, 2004]-
MeSH Terms:
Anti-Inflammatory Agents/*administration & dosage
Antioxidants/*administration & dosage
Osteoarthritis/*drug therapy
Plant Extracts/*administration & dosage
Rhodophyta/*chemistry
Animals ; Anti-Inflammatory Agents/chemistry ; Antioxidants/chemistry ; Disease Models, Animal ; Female ; Humans ; Osteoarthritis/immunology ; Plant Extracts/chemistry ; Rats ; Rats, Wistar
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Contributed Indexing:
Keywords: Actinotrichia fragilis; Inflammatory-Proteinase-Oxidant inhibitor; Osteoarthritis; Red algae
Substance Nomenclature:
0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Plant Extracts)
Entry Date(s):
Date Created: 20170509 Date Completed: 20170626 Latest Revision: 20200306
Update Code:
20240104
PubMed Central ID:
PMC5411875
DOI:
10.21010/ajtcam.v14i1.25
PMID:
28480401
Czasopismo naukowe
Background: Osteoarthritis (OA) is a progressive disease characterized by joints pain and articular cartilage destruction. Most of the current treatment strategies for OA are effective for symptoms relief but are accompanied with adverse side effect. Thus, the present investigation aims to evaluate the potential influence of red algae, Actinotrichia fragilis , in the dry powder form (AFP) or gel form (AFG) on some relevant factors of OA progression as well as assess its safety through in vitro and in vivo experiments.
Materials and Methods: In vitro , AFP was analyzed for its chemical constituents screening, amino acid, proteinase inhibitory activity, HRBC membrane stabilization activity, free radical scavenging activity, total antioxidant potency, nitric oxide radical scavenging power. In vivo , Organization for Economic Co-operation and Development (OECD) toxicity test was performed to test the safety of AFP on rats.
Results: The present findings revealed that AFP and AFG can be considered as inflammatory-proteinase-oxidant inhibitor and considered to be safe according to the OECD guideline.
Conclusion: AFP and AFG may have the potency to become the therapeutic candidate for OA disease as it prevents the key causes of OA initiation.

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