Comparison of the vaginal environment in rhesus and cynomolgus macaques pre- and post-lactobacillus colonization.

Tytuł:: Comparison of the vaginal environment in rhesus and cynomolgus macaques pre- and post-lactobacillus colonization.
Autorzy:: Daggett GJ Jr; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Zhao C; Libra Management Group, Atlanta, GA, USA.
Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Oviedo-Moreno P; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Moon H; Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University Ames, Ames, IA, USA.
Cho MW; Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University Ames, Ames, IA, USA.
Moench T; ReProtect Inc, Baltimore, MD, USA.
Anderson DJ; Departments of Obstetrics/Gynecology and Microbiology, Boston University, Boston, MA, USA.
Villinger F; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA, USA.
Źródło:: Journal of medical primatology [J Med Primatol] 2017 Oct; Vol. 46 (5), pp. 232-238. Date of Electronic Publication: 2017 May 09.
Typ publikacji:: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Publication: Copenhagen : Wiley
Original Publication: Basel, New York, Karger.
MeSH Terms:: Lactobacillus/*physiology
Macaca fascicularis/*microbiology
Macaca mulatta/*microbiology
Vagina/*microbiology
Animals ; Disease Models, Animal ; Female ; HIV Infections/prevention & control ; Humans ; Reference Values
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Grant Information:: P51 OD011132 United States OD NIH HHS; U19 AI096398 United States AI NIAID NIH HHS
Contributed Indexing:: Keywords: lactobacillus; macaque; microbiota; vagina
Entry Date(s):: Date Created: 20170511 Date Completed: 20180514 Latest Revision: 20220316
Update Code:: 20240104
PubMed Central ID:: PMC5597444
DOI:: 10.1111/jmp.12264
PMID:: 28488364
: Czasopismo naukowe

Pełny tekst

Background: Rhesus and cynomologus macaques are valuable animal models for the study of human immunodeficiency virus (HIV) prevention strategies. However, for such studies focused on the vaginal route of infection, differences in vaginal environment may have deterministic impact on the outcome of such prevention, providing the rationale for this study.
Methods: We tested the vaginal environment of rhesus and cynomolgus macaques longitudinally to characterize the normal microflora based on Nugent scores and pH. This evaluation was extended after colonization of the vaginal space with Lactobacilli in an effort to recreate NHP models representing the healthy human vaginal environment.
Results and Conclusion: Nugent scores and pH differed significantly between species, although data from both species were suggestive of stable bacterial vaginosis. Colonization with Lactobacilli was successful in both species leading to lower Nugent score and pH, although rhesus macaques appeared better able to sustain Lactobacillus spp over time.
(© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

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