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Tytuł:
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μ-Opioid and 5-HT1A receptors in the dorsomedial hypothalamus interact for the regulation of panic-related defensive responses.
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Autorzy:
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Roncon CM; 1 Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Yamashita PSM; 1 Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.; 2 Department of Integrative Physiology and Center for Neuroscience, University of Colorado, Boulder, CO, USA.
Frias AT; 1 Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Audi EA; 3 Laboratory of Psychopharmacology, Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, Paraná, Brazil.
Graeff FG; 4 Behavioural Neurosciences Institute (INeC), Ribeirão Preto, São Paulo, Brazil.; 5 NAP-USP-Neurobiology of Emotions Research Centre (NuPNE), FMRP-USP, Ribeirão Preto, São Paulo, Brazil.
Coimbra NC; 1 Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.; 4 Behavioural Neurosciences Institute (INeC), Ribeirão Preto, São Paulo, Brazil.; 5 NAP-USP-Neurobiology of Emotions Research Centre (NuPNE), FMRP-USP, Ribeirão Preto, São Paulo, Brazil.
Zangrossi H; 1 Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.; 4 Behavioural Neurosciences Institute (INeC), Ribeirão Preto, São Paulo, Brazil.; 5 NAP-USP-Neurobiology of Emotions Research Centre (NuPNE), FMRP-USP, Ribeirão Preto, São Paulo, Brazil.
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Źródło:
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Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2017 Jun; Vol. 31 (6), pp. 715-721. Date of Electronic Publication: 2017 Feb 01.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: Thousand Oaks, CA : Sage Publications
Original Publication: Oxford, UK : Oxford University Press,
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MeSH Terms:
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Hypothalamus/*metabolism
Panic/*physiology
Panic Disorder/*metabolism
Receptor, Serotonin, 5-HT1A/*metabolism
Receptors, Opioid, mu/*metabolism
8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology ; Analgesics, Opioid/pharmacology ; Animals ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology ; Escape Reaction/drug effects ; Escape Reaction/physiology ; Hypothalamus/drug effects ; Male ; Naloxone/pharmacology ; Panic/drug effects ; Periaqueductal Gray/drug effects ; Periaqueductal Gray/metabolism ; Piperazines/pharmacology ; Pyridines/pharmacology ; Rats ; Rats, Wistar ; Serotonin/pharmacology ; Somatostatin/analogs & derivatives ; Somatostatin/pharmacology
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Contributed Indexing:
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Keywords: Panic; dorsomedial hypothalamus; electrical stimulation; endogenous opioid; serotonin
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Substance Nomenclature:
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0 (Analgesics, Opioid)
0 (Piperazines)
0 (Pyridines)
0 (Receptors, Opioid, mu)
100929-53-1 (Enkephalin, Ala(2)-MePhe(4)-Gly(5)-)
103429-31-8 (phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide)
112692-38-3 (Receptor, Serotonin, 5-HT1A)
333DO1RDJY (Serotonin)
36B82AMQ7N (Naloxone)
51110-01-1 (Somatostatin)
71IH826FEG (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide)
78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
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Entry Date(s):
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Date Created: 20170607 Date Completed: 20180322 Latest Revision: 20181021
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Update Code:
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20240104
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DOI:
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10.1177/0269881117693747
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PMID:
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28583050
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The dorsomedial hypothalamus (DMH) and the dorsal periaqueductal gray (DPAG) have been implicated in the genesis and regulation of panic-related defensive behaviors, such as escape. Previous results point to an interaction between serotonergic and opioidergic systems within the DPAG to inhibit escape, involving µ-opioid and 5-HT1A receptors (5-HT1AR). In the present study we explore this interaction in the DMH, using escape elicited by electrical stimulation of this area as a panic attack index. The obtained results show that intra-DMH administration of the non-selective opioid receptor antagonist naloxone (0.5 nmol) prevented the panicolytic-like effect of a local injection of serotonin (20 nmol). Pretreatment with the selective μ-opioid receptor (MOR) antagonist CTOP (1 nmol) blocked the panicolytic-like effect of the 5-HT1AR agonist 8-OHDPAT (8 nmol). Intra-DMH injection of the selective MOR agonist DAMGO (0.3 nmol) also inhibited escape behavior, and a previous injection of the 5-HT1AR antagonist WAY-100635 (0.37 nmol) counteracted this panicolytic-like effect. These results offer the first evidence that serotonergic and opioidergic systems work together within the DMH to inhibit panic-like behavior through an interaction between µ-opioid and 5-HT1A receptors, as previously described in the DPAG.
