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Tytuł pozycji:

Ovarian Cancer in Elderly Patients: Patterns of Care and Treatment Outcomes According to Age and Modified Frailty Index.

Tytuł:
Ovarian Cancer in Elderly Patients: Patterns of Care and Treatment Outcomes According to Age and Modified Frailty Index.
Autorzy:
Ferrero A; Academic Department of Gynaecology and Obstetrics, University of Torino, Mauriziano Hospital, Torino; and †Division of Gynaecology and Obstetrics, Department of Experimental and Clinical Medicine, University of Pisa, Pisa, Italy.
Fuso L
Tripodi E
Tana R
Daniele A
Zanfagnin V
Perotto S
Gadducci A
Źródło:
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2017 Nov; Vol. 27 (9), pp. 1863-1871.
Typ publikacji:
Journal Article; Multicenter Study
Język:
English
Imprint Name(s):
Publication: 2019- : [London] : BMJ
Original Publication: Cambridge, MA, USA : Blackwell Scientific Publications, c1991-
MeSH Terms:
Neoplasms, Glandular and Epithelial/*drug therapy
Neoplasms, Glandular and Epithelial/*surgery
Ovarian Neoplasms/*drug therapy
Ovarian Neoplasms/*surgery
Age Factors ; Aged ; Aged, 80 and over ; Carcinoma, Ovarian Epithelial ; Female ; Frail Elderly ; Geriatric Assessment ; Humans ; Retrospective Studies ; Treatment Outcome
Entry Date(s):
Date Created: 20170802 Date Completed: 20180319 Latest Revision: 20190221
Update Code:
20240105
DOI:
10.1097/IGC.0000000000001097
PMID:
28763363
Czasopismo naukowe
Objective: The present study assessed the predictive value of age and Modified Frailty Index (mFI) on the management of primary epithelial ovarian cancer (EOC) patients aged 70 years or older (elderly).
Methods: A retrospective multicenter study selected elderly EOC patients treated between 2006 and 2014. Treatments were analyzed according to the following age group categories: (1) 70 to 75 years versus (2) older than 75 years, and mFI of less than 4 (low frailty) versus greater than or equal to 4 (high frailty).
Results: Seventy-eight patients were identified (40 in age group 1 and 38 in age group 2). The mFI was greater than or equal to 4 in 23 women. Median age of low frailty and high frailty was not significantly different (75.6 vs 75.3). Comorbidities were equally distributed according to age, whereas diabetes, hypertension, obesity, and chronic renal failure were more frequent in the high-frailty group. Performance status was different only according to mFI. Twenty percent of age group 1 versus 55.3% of age group 2 underwent none or only explorative surgical approach (P = 0.003), whereas surgical approaches were similar in the 2 frailty groups. The rate of postoperative complications was higher in high-frailty patients compared with low-frailty patients (23.5% vs 4.3%; P = 0.03). Chemotherapy was administered to all the patients, a monotherapy regimen to 50% of them. No differences in toxicity were registered, except more hospital recovery in the high-frailty cohort. Median survival time was in favor of younger patients (98 versus 30 months) and less-frailty patients (56 vs 27 months).
Conclusions: Elderly EOC patients can receive an adequate treatment, but patients who are older than 75 years can be undertreated, if not adequately selected. The pretreatment assessment of frailty through mFI could be suggested in the surgical and medical management.

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