Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.

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Abstrakt

Tytuł:: Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies.
Autorzy:: Oussalah A; Department of Molecular Medicine and Personalized Therapeutics.; Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, and.; INSERM, Unité 954, Nutrition, Genetics, and Environmental Risk Exposure, Faculty of Medicine of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.
Levy J; Department of Molecular Medicine and Personalized Therapeutics.; Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, and.
Filhine-Trésarrieu P; Department of Molecular Medicine and Personalized Therapeutics.; Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, and.; INSERM, Unité 954, Nutrition, Genetics, and Environmental Risk Exposure, Faculty of Medicine of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.
Namour F; Department of Molecular Medicine and Personalized Therapeutics.; Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, and.; INSERM, Unité 954, Nutrition, Genetics, and Environmental Risk Exposure, Faculty of Medicine of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.
Guéant JL; Department of Molecular Medicine and Personalized Therapeutics, .; Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, and.; INSERM, Unité 954, Nutrition, Genetics, and Environmental Risk Exposure, Faculty of Medicine of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.
Źródło:: The American journal of clinical nutrition [Am J Clin Nutr] 2017 Oct; Vol. 106 (4), pp. 1142-1156. Date of Electronic Publication: 2017 Aug 16.
Typ publikacji:: Journal Article; Meta-Analysis; Review; Systematic Review
Język:: English
Imprint Name(s):: Publication: 2023- : [New York, NY] : Elsevier
Original Publication: Bethesda, MD : American Society of Clinical Nutrition
MeSH Terms:: Alleles*
Genotype*
Polymorphism, Single Nucleotide*
Homocysteine/*blood
Transcobalamins/*genetics
Vitamin B 12/*blood
Vitamin B 12 Deficiency/*genetics
Adult ; Aged ; Alzheimer Disease/etiology ; Alzheimer Disease/genetics ; Carbon/blood ; Child ; Congenital Abnormalities/etiology ; Congenital Abnormalities/genetics ; Female ; Humans ; Male ; Methylmalonic Acid/metabolism ; Neoplasms/etiology ; Neoplasms/genetics ; Transcobalamins/metabolism ; Vitamin B 12 Deficiency/blood ; Vitamin B 12 Deficiency/complications ; White People/genetics
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Contributed Indexing:: Keywords: c.776G>C; cobalamin; genetic association studies; holotranscobalamin; homocysteine; meta-analysis; one-carbon metabolism; rs1801198; transcobalamin; transcobalamin II
Substance Nomenclature:: 0 (Transcobalamins)
0LVT1QZ0BA (Homocysteine)
7440-44-0 (Carbon)
8LL8S712J7 (Methylmalonic Acid)
P6YC3EG204 (Vitamin B 12)
Entry Date(s):: Date Created: 20170818 Date Completed: 20171013 Latest Revision: 20230214
Update Code:: 20240105
PubMed Central ID:: PMC5611783
DOI:: 10.3945/ajcn.117.156349
PMID:: 28814397
: Czasopismo naukowe

Background: Vitamin B-12 (cobalamin) deficiency may produce severe neurologic and hematologic manifestations. Approximately 20-25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is referred to as active vitamin B-12. The G allele of the TCN2 c.776G>C (rs1801198) polymorphism has been associated with a lower plasma concentration of holotranscobalamin. However, genotype association studies on rs1801198 have led to conflicting results regarding its influence on one-carbon metabolism (OCM) markers or its association with pathologic conditions. Objective: We assessed the association of rs1801198 genotypes with OCM marker concentrations and primary risks of congenital abnormalities, cancer, and Alzheimer disease. Design: We conducted a systematic review of the literature that was published from January 1966 to February 2017 and included all studies that assessed the association between rs1801198 and OCM markers or a pathologic condition. Results: Thirty-four studies met the inclusion criteria. Subjects with the rs1801198 GG genotype had significantly lower concentrations of holotranscobalamin [standardized mean difference (SMD): -0.445 (95% CI: -0.673, -0.217; P < 0.001); I 2 = 48.16% (95% CI: 0.00%, 78.10%; P = 0.07)] and higher concentrations of homocysteine (European descent only) [SMD: 0.070 (95% CI: 0.020, 0.120; P = 0.01); I 2 = 0.00% (95% CI: 0.00%, 49.59%; P = 0.73)] than did subjects with the rs1801198 CC genotype. The meta-analysis on the association between rs1801198 and methylmalonic acid (MMA) lacked statistical power. No significant difference was observed regarding cobalamin, folate, and red blood cell folate. No significant association was observed between rs1801198 and primary risks of congenital abnormalities, cancer, or Alzheimer disease. Conclusions: Meta-analysis results indicate an influence of rs1801198 on holotranscobalamin and homocysteine concentrations in European-descent subjects. In addition, well-designed and -powered studies should be conducted for assessing the association between rs1801198 and MMA and clinical manifestations that are linked to a decreased availability of cobalamin. This review was registered at www.crd.york.ac.uk/prospero as CRD42017058504.
(© 2017 American Society for Nutrition.)

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