Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica.

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Tytuł:: Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica.
Autorzy:: Ito C; a Faculty of Pharmacy , Meijo University , Tempaku , Japan.
Matsui T; a Faculty of Pharmacy , Meijo University , Tempaku , Japan.; b Department of Physiology , Aichi Medical University , Nagakute , Japan.
Takano M; a Faculty of Pharmacy , Meijo University , Tempaku , Japan.
Wu TS; c Department of Chemistry , National Cheng Kung University , Tainan , Taiwan.
Itoigawa M; d School of Sport and Health Science , Tokai Gakuen University , Miyoshi , Japan.
Źródło:: Natural product research [Nat Prod Res] 2018 Sep; Vol. 32 (18), pp. 2127-2132. Date of Electronic Publication: 2017 Aug 20.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
MeSH Terms:: Antineoplastic Agents/*isolation & purification
Cell Proliferation/*drug effects
Naphthoquinones/*pharmacology
Plumbaginaceae/*chemistry
Antineoplastic Agents/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Dimerization ; Humans ; Naphthoquinones/chemistry ; Naphthoquinones/isolation & purification ; Plant Roots/chemistry ; Taiwan
Contributed Indexing:: Keywords: Plumbaginaceae; Plumbago zeylanica; cell cycle; cell proliferation; naphthoquinones
Substance Nomenclature:: 0 (Antineoplastic Agents)
0 (Naphthoquinones)
0 (maritinone)
YAS4TBQ4OQ (plumbagin)
Entry Date(s):: Date Created: 20170822 Date Completed: 20180925 Latest Revision: 20181004
Update Code:: 20240105
DOI:: 10.1080/14786419.2017.1366476
PMID:: 28823173
: Czasopismo naukowe

Study of the chemical constituents of the roots of Plumbago zeylanica L. collected in Taiwan led to the isolation and identification of a new naphthoquinone dimer, plumzeylanone (1), along with eight known compounds (2-9). Nine naphthoquinones isolated from this plant were assayed for cell growth inhibition activity using NALM-6 (human B cell precursor leukaemia), A549 (human lung adenocarcinoma), Colo205 (human colorectal adenocarcinoma) and KB (human epidermoid carcinoma). Plumzeylanone (1), a novel plumbagin dimer, suppressed cell proliferation in only NALM-6 cells (IC 50 3.98 μM). However, maritinone (9) showed strong inhibition of cell growth in all cell lines tested (0.12 < IC 50 < 9.06 μM). This compound appeared to affect the cell cycle.

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