Single nucleotide polymorphisms at miR-146a/196a2 and their primary ovarian insufficiency-related target gene regulation in granulosa cells.

Szczegóły
Abstrakt

Tytuł:: Single nucleotide polymorphisms at miR-146a/196a2 and their primary ovarian insufficiency-related target gene regulation in granulosa cells.
Autorzy:: Cho SH; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
An HJ; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Kim KA; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Ko JJ; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Kim JH; Department of Obstetrics and Gynecology, School of Medicine, CHA University, Seongnam, South Korea.
Kim YR; Department of Obstetrics and Gynecology, School of Medicine, CHA University, Seongnam, South Korea.
Ahn EH; Department of Obstetrics and Gynecology, School of Medicine, CHA University, Seongnam, South Korea.
Rah H; Healthcare Bigdata Linkage Platform Team, Chungbuk National University, Cheongju, Chungbuk, South Korea.
Lee WS; Fertility Center of CHA Gangnam Medical Center, School of Medicine, CHA University, Seoul, South Korea.
Kim NK; Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
Źródło:: PloS one [PLoS One] 2017 Aug 25; Vol. 12 (8), pp. e0183479. Date of Electronic Publication: 2017 Aug 25 (Print Publication: 2017).
Typ publikacji:: Journal Article; Validation Study
Język:: English
Imprint Name(s):: Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:: Gene Expression Regulation*
Polymorphism, Single Nucleotide*
Granulosa Cells/*metabolism
MicroRNAs/*genetics
Primary Ovarian Insufficiency/*genetics
3' Untranslated Regions ; Adult ; Female ; Humans ; Young Adult
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Substance Nomenclature:: 0 (3' Untranslated Regions)
0 (MIRN146 microRNA, human)
0 (MIRN196 microRNA, human)
0 (MicroRNAs)
Entry Date(s):: Date Created: 20170826 Date Completed: 20171019 Latest Revision: 20191210
Update Code:: 20240105
PubMed Central ID:: PMC5571913
DOI:: 10.1371/journal.pone.0183479
PMID:: 28841705
: Czasopismo naukowe

Pełny tekst

MicroRNAs post-transcriptionally regulate gene expression in animals and plants. The aim of this study was to identify new target genes for microRNA polymorphisms (miR-146aC>G and miR-196a2T>C) in primary ovarian insufficiency (POI). We cloned and transfected miR-146aC>G and miR-196a2T>C into human granulosa cells and used microarrays and qPCR-arrays to examine the changes in the messenger RNA expression profile. We show miR-146aC>G and miR-196a2T>C change the mRNA expression patterns in granulosa cell. In each case, mRNAs were up or down-regulated after treatments with miR-146a C or G and miR-196a2 T or C. We found that miR-146a led to a significantly altered regulation of the mRNA levels of FOXO3, FOXL2 and CCND2 compared to controls. We also found that the polymorphisms of miR-146a led to a significantly altered regulation of CCND2 and FOXO3. Our results suggest that miR-146aC>G and miR-196a2T>C can regulate the levels of many of their target transcripts. In addition, specific target genes of miR-146aC>G polymorphisms may be involved in granulosa cell regulation.

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