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Tytuł pozycji:

Genetic variation in angiotensin converting-enzyme affects the white matter integrity and cognitive function of amnestic mild cognitive impairment patients.

Tytuł :
Genetic variation in angiotensin converting-enzyme affects the white matter integrity and cognitive function of amnestic mild cognitive impairment patients.
Autorzy :
Li Y; Geriatric Department of Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, China.
Zhang Z; Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu 210009, China.
Deng L; School of Clinical Medicine, Southeast University, Nanjing 210009, China.
Bai F; Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu 210009, China.
Shi Y; Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu 210009, China.
Yu H; School of Clinical Medicine, Southeast University, Nanjing 210009, China.
Xie C; Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu 210009, China.
Yuan Y; Psychiatric Department of Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, China.
Zhang Z; Geriatric Department of Affiliated ZhongDa Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, China. Electronic address: .
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Źródło :
Journal of the neurological sciences [J Neurol Sci] 2017 Sep 15; Vol. 380, pp. 177-181. Date of Electronic Publication: 2017 Jun 16.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Amsterdam : Elsevier, <19 ->
MeSH Terms :
Cognitive Dysfunction*/blood
Cognitive Dysfunction*/genetics
Cognitive Dysfunction*/pathology
Cognitive Dysfunction*/physiopathology
Cognition/*physiology
Peptidyl-Dipeptidase A/*genetics
Polymorphism, Single Nucleotide/*genetics
White Matter/*pathology
Aged ; Anisotropy ; Diffusion Tensor Imaging ; Female ; Gene Frequency ; Gyrus Cinguli/diagnostic imaging ; Humans ; Male ; Neuropsychological Tests ; Peptidyl-Dipeptidase A/blood ; White Matter/diagnostic imaging
Contributed Indexing :
Keywords: Angiotensin converting enzyme; Cognitive function; Diffusion tensor imaging; Gene; Magnetic resonance imaging; Mild cognitive impairment
Substance Nomenclature :
EC 3.4.15.1 (Peptidyl-Dipeptidase A)
Entry Date(s) :
Date Created: 20170906 Date Completed: 20180508 Latest Revision: 20180508
Update Code :
20210210
DOI :
10.1016/j.jns.2017.06.026
PMID :
28870562
Czasopismo naukowe
Angiotensin-converting enzyme (ACE) gene has been implicated in amnestic mild cognitive impairment (aMCI). Most human genetic studies have focused on ACE insertion (I)/deletion (D) polymorphism and yielded conflicting results. In this work, we evaluated the relationships between cognitive function, serum ACE level, brain white matter (WM) integrity, and ACE I/D polymorphism in 48 patients with aMCI and 36 well matched control subjects from south China. In aMCI patients, D allele frequency was higher (D/I ratio=0.51:0.49) than that of the control subjects (D/I ratio=0.43:0.57); however, the difference was not statistically significant (p>0.05). The D carriers in aMCI subjects performed significantly poorer on auditory-verbal learning test (AVLT) -delayed recall than the I homozygous group (p=0.035). These carriers had higher serum ACE level than the I homozygous carriers of aMCI (p=0.037). In the aMCI group, D carriers showed significantly lower fractional anisotropy (FA) values in the left middle frontal gyrus, left anterior cingulate, right gyrus parahippocampalis, right inferior parietal lobule, and bilateral anterior central gyrus than the I homozygotes carriers. However, no significant difference was observed in FA values between I homozygotes and D carriers in the control subjects. The ACE D allele in aMCI patients may increase the risk of cognitive impairment. A high serum ACE level possibly plays an important role in the incidence of aMCI.
(Copyright © 2017. Published by Elsevier B.V.)

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