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Tytuł pozycji:

Increased whole cerebellar serotonin in aged C57BL/6 mice.

Tytuł:
Increased whole cerebellar serotonin in aged C57BL/6 mice.
Autorzy:
DeKorver NW; Internal Medicine, University of Nebraska Medical Center; Microdialysis, Brains Online.
Lichty D; Internal Medicine, University of Nebraska Medical Center; Microdialysis, Brains Online.
van der Hart M; Internal Medicine, University of Nebraska Medical Center; Microdialysis, Brains Online.
Rassoulpour A; Internal Medicine, University of Nebraska Medical Center; Microdialysis, Brains Online.
Bonasera SJ; Internal Medicine, University of Nebraska Medical Center; Microdialysis, Brains Online.
Źródło:
Matters [Matters (Zur)] 2017; Vol. 2017. Date of Electronic Publication: 2017 Mar 09.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Zurich : Sciencematters AG
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Grant Information:
R01 AG031158 United States AG NIA NIH HHS
Contributed Indexing:
Keywords: Aging; Cerebellum; Mouse; Serotonin
Entry Date(s):
Date Created: 20170913 Latest Revision: 20201001
Update Code:
20240105
PubMed Central ID:
PMC5591457
DOI:
10.19185/matters.201702000011
PMID:
28894740
Czasopismo naukowe
Mobility and locomotor impairments have high prevalence, morbidity, and significant mortality in older adult populations. Cerebellar functional changes have been implicated in the pathogenesis of these age-related mobility and gait deficits unrelated to stroke, Parkinson's disease, or degenerative joint disease. We thus examined total cerebellar glutamate, glutamine, GABA, glycine, dopamine, norepinephrine, tryptophan, serotonin, alanine, threonine, and asparagine content from male 2-3-month (young, n = 6) and 21-24-month-old (aged, n = 6) C 57 BL/6 mice. Neurotransmitter and amino acid concentrations were determined by high-performance liquid chromatography followed with mass spectroscopy. We found a significant increase in cerebellar serotonin in aged versus young mice, but otherwise no significant phenotypic differences in measured neurotransmitter concentrations. Applying current thought about cerebellar aging and cerebellar serotonergic systems, we consider how this age-related increase in cerebellar serotonin may contribute to gait ataxia.

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