Therapeutic uses of epicatechin in diabetes and cancer.

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Abstrakt

Tytuł:: Therapeutic uses of epicatechin in diabetes and cancer.
Autorzy:: Abdulkhaleq LA; Department of Veterinary Laboratory Diagnostics, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.; Department of Pathology and Poultry Diseases, Faculty of Veterinary Medicine, Baghdad University, Baghdad, Iraq.
Assi MA; Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.; Department of Community Health, College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, Iraq.
Noor MHM; Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Abdullah R; Department of Veterinary Laboratory Diagnostics, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Saad MZ; Department of Veterinary Laboratory Diagnostics, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Taufiq-Yap YH; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Źródło:: Veterinary world [Vet World] 2017 Aug; Vol. 10 (8), pp. 869-872. Date of Electronic Publication: 2017 Aug 06.
Typ publikacji:: Journal Article; Review
Język:: English
Imprint Name(s):: Publication: Dist. Morbi (Gujarat), India : Veterinary World
Original Publication: Rajkot (Gujarat), India : Veterinary World, [2008]-
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Contributed Indexing:: Keywords: angiogenesis; carcinoma; diabetes mellitus; epicatechin; oxidative stress
Entry Date(s):: Date Created: 20170919 Latest Revision: 20201001
Update Code:: 20240104
PubMed Central ID:: PMC5591471
DOI:: 10.14202/vetworld.2017.869-872
PMID:: 28919675
: Czasopismo naukowe

Pełny tekst

Epicatechin is a natural flavonoid found in green tea. It has been reported to possess an immense antioxidant effect which contributes to its therapeutic effect against a handful of ailments. In this review, we discuss its therapeutic role in the management of two of the most important human diseases; diabetes and cancer. The consumption of epicatechin has been shown to reduce blood glucose levels in diabetic patients, while is anticancer effect was attributed to its antioxidant properties, antiangiogenic and direct cytotoxicity to cancer cells. Although the exact mechanism of action of epicatechin is still being explored, there is no doubt that it is a promising candidate as an alternative. The significance of this review is to highlight the importance of the usage of natural products (in this case, epicatechin) as an alternative for the treatment of two potentially fatal diseases which is diabetes and cancer. The aim of this review is to educate the scientific community on the role of epicatechin in ameliorating the effects of diabetes and cancers on human while understanding the potential mechanisms of these aforementioned effects.

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