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Tytuł pozycji:

Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease.

Tytuł:
Adipokine and Cytokine Profiles of Epicardial and Subcutaneous Adipose Tissue in Patients with Coronary Heart Disease.
Autorzy:
Gruzdeva OV; Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia. o_.
Akbasheva OE; Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Dyleva YA; Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.
Antonova LV; Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.
Matveeva VG; Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.
Uchasova EG; Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.
Fanaskova EV; Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.
Karetnikova VN; Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.
Ivanov SV; Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.
Barbarash OL; Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia.
Źródło:
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Sep; Vol. 163 (5), pp. 608-611. Date of Electronic Publication: 2017 Sep 25.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
MeSH Terms:
Adipokines/*metabolism
Adipose Tissue/*metabolism
Coronary Disease/*metabolism
Cytokines/*metabolism
Subcutaneous Fat/*metabolism
Adipocytes/metabolism ; Aged ; Female ; Fibroblast Growth Factors/metabolism ; Humans ; Interleukin-1/metabolism ; Interleukin-10/metabolism ; Male ; Middle Aged ; Tumor Necrosis Factor-alpha/metabolism
Contributed Indexing:
Keywords: adipocytes; cytokines; epicardial adipose tissue; subcutaneous fat
Substance Nomenclature:
0 (Adipokines)
0 (Cytokines)
0 (Interleukin-1)
0 (Tumor Necrosis Factor-alpha)
130068-27-8 (Interleukin-10)
62031-54-3 (Fibroblast Growth Factors)
Entry Date(s):
Date Created: 20170927 Date Completed: 20180611 Latest Revision: 20180611
Update Code:
20240105
DOI:
10.1007/s10517-017-3860-5
PMID:
28948552
Czasopismo naukowe
The content of adipokines, pro- and anti-inflammatory cytokines were studied in adipocytes isolated from epicardial and subcutaneous adipose tissue of 24 coronary heart disease patients. The content of leptin and soluble leptin receptor in adipocytes of epicardial adipose tissue was higher by 28.6 and 56.9% and the level of adiponectin was lower by 33% than in adipocytes of the subcutaneous fat. In culture of epicardial adipocytes, the levels of proinflammatory cytokines TNF-α and IL-1 were higher. Subcutaneous adipose tissue adipocytes were characterized by higher levels of anti-inflammatory cytokines IL-10 and FGF-β. In epicardial adipocytes of coronary heart disease patients, the concentrations of leptin, TNF-α, and IL-1 were higher, while the levels of defense regulatory molecules (adiponectin, IL-10, and FGF-β) were lower than in subcutaneous adipocytes.

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