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Tytuł pozycji:

U-47700: A Not So New Opioid.

Tytuł :
U-47700: A Not So New Opioid.
Autorzy :
Rohrig TP; Regional Forensic Science Center, 1109 N. Minneapolis, Wichita, KS 67214,USA.
Miller SA; Regional Forensic Science Center, 1109 N. Minneapolis, Wichita, KS 67214,USA.
Baird TR; Regional Forensic Science Center, 1109 N. Minneapolis, Wichita, KS 67214,USA.
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Źródło :
Journal of analytical toxicology [J Anal Toxicol] 2018 Jan 01; Vol. 42 (1), pp. e12-e14.
Typ publikacji :
Case Reports; Journal Article
Język :
English
Imprint Name(s) :
Publication: 2012- : Oxford : Oxford University Press
Original Publication: 1977-<2011>: Niles, Ill., Preston Publications.
MeSH Terms :
Analgesics, Opioid/*poisoning
Benzamides/*poisoning
Opioid-Related Disorders/*etiology
Adult ; Analgesics, Opioid/blood ; Autopsy ; Benzamides/blood ; Cause of Death ; Chromatography, Liquid ; Drug Overdose ; Fatal Outcome ; Gas Chromatography-Mass Spectrometry ; Humans ; Male ; Opioid-Related Disorders/blood ; Opioid-Related Disorders/diagnosis ; Substance Abuse Detection/methods ; Tandem Mass Spectrometry
Substance Nomenclature :
0 (Analgesics, Opioid)
0 (Benzamides)
0 (U-47700)
Entry Date(s) :
Date Created: 20171018 Date Completed: 20180918 Latest Revision: 20180918
Update Code :
20210914
DOI :
10.1093/jat/bkx081
PMID :
29040568
Czasopismo naukowe
U-47700 was developed by the Upjohn Co. in the 1970s as part of their search for a selective μ-opioid agonist with similar potency as morphine. U-47700 has re-emerged recently in the illicit drug market and is easily and cheaply obtained via the internet as well as on the street, many times falsely sold as another drug. Several fatalities from U-47700 have been reported in scientific literature, often in combination with other intoxicants. This case report describes the first death in south-central Kansas resulting solely from U-47700 intoxication: a 26-year-old white male found dead in his bedroom with apparent drug paraphernalia. Autopsy findings were consistent with opioid overdose, but toxicological examination, utilizing immunoassay and instrumental techniques, was negative for opioids. U-47700 was detected in a comprehensive alkaloid screen by GC/MS and GC-NPD, and quantitation was performed using GC-NPD on a variety of specimens to provide a full tissue distribution. Quantitation of U-47700 in this individual revealed the following: heart blood 0.26 mg/L, femoral blood 0.40 mg/L, vitreous fluid 0.09 mg/L, brain 0.38 mg/kg, liver 0.28 mg/kg and urine 4.6 mg/L.

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