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Tytuł pozycji:

Fine chalk dust induces inflammatory response via p38 and ERK MAPK pathway in rat lung.

Tytuł:
Fine chalk dust induces inflammatory response via p38 and ERK MAPK pathway in rat lung.
Autorzy:
Zhang Y; Institute of Environmental Science, Shanxi University, Wucheng Road 92#, Taiyuan, 030006, Shanxi Province, People's Republic of China.
Yang Z; Institute of Environmental Science, Shanxi University, Wucheng Road 92#, Taiyuan, 030006, Shanxi Province, People's Republic of China.
Chen Y; Institute of Environmental Science, Shanxi University, Wucheng Road 92#, Taiyuan, 030006, Shanxi Province, People's Republic of China.
Li R; Institute of Environmental Science, Shanxi University, Wucheng Road 92#, Taiyuan, 030006, Shanxi Province, People's Republic of China.
Geng H; Institute of Environmental Science, Shanxi University, Wucheng Road 92#, Taiyuan, 030006, Shanxi Province, People's Republic of China.
Dong W; Institute of Environmental Science, Shanxi University, Wucheng Road 92#, Taiyuan, 030006, Shanxi Province, People's Republic of China.
Cai Z; State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, SAR, China. .
Dong C; Institute of Environmental Science, Shanxi University, Wucheng Road 92#, Taiyuan, 030006, Shanxi Province, People's Republic of China. .
Źródło:
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2018 Jan; Vol. 25 (2), pp. 1742-1751. Date of Electronic Publication: 2017 Nov 03.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed
MeSH Terms:
Air Pollutants/*toxicity
Calcium Carbonate/*toxicity
Inflammation/*genetics
Lung/*drug effects
MAP Kinase Signaling System/*drug effects
p38 Mitogen-Activated Protein Kinases/*metabolism
Acetylcysteine/therapeutic use ; Animals ; Dietary Supplements ; Dust ; Inflammation/chemically induced ; Lung/metabolism ; Lung/pathology ; Male ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Up-Regulation/drug effects
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Grant Information:
21575084 the National Natural Science Foundation of China; 21405099 the National Natural Science Foundation of China; 91543202 the key Program of National Natural Science of China; 201601D202087 Nature Science Foundation of Shanxi Province in China; 2014110 Foundation of Educational Committee of Shanxi Province in China
Contributed Indexing:
Keywords: Fine chalk dust; Inflammation; Lung; Pathway
Substance Nomenclature:
0 (Air Pollutants)
0 (Dust)
EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
H0G9379FGK (Calcium Carbonate)
WYQ7N0BPYC (Acetylcysteine)
Entry Date(s):
Date Created: 20171105 Date Completed: 20181107 Latest Revision: 20181113
Update Code:
20240104
DOI:
10.1007/s11356-017-0558-1
PMID:
29101699
Czasopismo naukowe
Chalk teaching is widely used in the world due to low cost, especially in some developing countries. During teaching with chalks, a large amount of fine chalk dust is produced. Although exposure to chalk dust is associated with respiratory diseases, the mechanism underlying the correlation between chalk dust exposure and adverse effects has not fully been elucidated. In this study, inflammation and its signal pathway in rat lungs exposed to fine chalk dust were examined through histopathology analyses; pro-inflammatory gene transcription; and protein levels measured by HE staining, RT-PCR, and western blot analysis. The results demonstrated that fine chalk dust increased neutrophils and up-regulated inflammatory gene mRNA levels (TNF-α, IL-6, TGF-β1, iNOS, and ICAM-1), and oxidative stress marker (HO-1) level, leading to the increase of inflammatory cell infiltration and inflammatory injury on the lungs. These inflammation responses were mediated, at least in part, via p38 and extracellular regulated proteinase (ERK) mitogen-activated protein kinase (MAPK) signaling mechanisms. In contrast, N-acetyl-L-cysteine (NAC) supplement significantly ameliorated these changes in inflammatory responses. Our results support the hypothesis that fine chalk dust can damage rat lungs and the NAC supplement may attenuate fine chalk dust-associated lung inflammation.

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