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Tytuł:
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MR textural analysis on T 2 FLAIR images for the prediction of true oligodendroglioma by the 2016 WHO genetic classification.
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Autorzy:
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Rui W; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
Ren Y; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
Wang Y; Department of Neuropathology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
Gao X; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
Xu X; GE Healthcare Life Sciences, GE Chinese Science and Technology Park, Shanghai, P.R. China.
Yao Z; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P.R. China.
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Źródło:
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Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2018 Jul; Vol. 48 (1), pp. 74-83. Date of Electronic Publication: 2017 Nov 15.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: <2005-> : Hoboken , N.J. : Wiley-Liss
Original Publication: Chicago, IL : Society for Magnetic Resonance Imaging, c1991-
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MeSH Terms:
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Magnetic Resonance Imaging*
Oligodendroglioma/*diagnostic imaging
Adult ; Area Under Curve ; Astrocytoma/genetics ; Biopsy ; Brain Neoplasms/genetics ; Case-Control Studies ; Chromosomes, Human, Pair 1 ; Female ; Glioma/diagnostic imaging ; Humans ; Isocitrate Dehydrogenase/genetics ; Male ; Middle Aged ; Models, Theoretical ; Mutation ; Observer Variation ; Predictive Value of Tests ; ROC Curve ; Retrospective Studies ; Sensitivity and Specificity ; World Health Organization ; Young Adult
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Contributed Indexing:
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Keywords: 1p/19q; IDH-mutant; T2 FLAIR; magnetic resonance textural analysis; oligodendroglioma
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Substance Nomenclature:
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EC 1.1.1.41 (Isocitrate Dehydrogenase)
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Entry Date(s):
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Date Created: 20171116 Date Completed: 20190916 Latest Revision: 20190916
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Update Code:
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20240105
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DOI:
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10.1002/jmri.25896
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PMID:
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29140606
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Background: The genetic status of 1p/19q is important for differentiating oligodendroglioma, isocitrate-dehydrogenase (IDH)-mutant, and 1p/19q-codeleted from diffuse astrocytoma, IDH-mutant according to the 2016 World Health Organization (WHO) criteria.
Purpose: To assess the value of magnetic resonance textural analysis (MRTA) on T 2 fluid-attenuated inversion recovery (FLAIR) images for making a genetically integrated diagnosis of true oligodendroglioma by WHO guidelines.
Study Type: Retrospective case control.
Subjects: In all, there were 54 patients with a histopathological diagnosis of diffuse glioma (grade II). All were tested for IDH and 1p/19q.
Field Strength/sequence: 3.0T, including T 2 FLAIR sequence, axial T 1 -weighted, and T 2 -weighted sequence.
Assessment: MRTA on a representative tumor region of interest (ROI) was made on preoperative T 2 FLAIR images around the area that had the largest diameter of solid tumor using Omni Kinetics software.
Statistical Tests: Differences between IDH-mutant and 1p/19q-codeleted and IDH-mutant and 1p/19q-intact gliomas were analyzed by the Mann-Whitney rank sum test. Receiver operating characteristic curves (ROC) were created to assess MRTA diagnostic performance. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated with a cutoff value according to the Youden Index.
Results: Comparisons demonstrated significant differences in kurtosis (P = 0.007), energy (0.008), entropy (0.008), mean deviation (MD) (<0.001), and high gray-level run emphasis (HGLRE) (0.002), cluster shade (0.025), and sum average (0.002). First-order features comprising entropy (area under the curve [AUC] = 0.718, sensitivity = 97.1%) and energy (0.719, 94.1%) had the highest sensitivity but lower specificity (both 45%). Second-order features such as HGLRE (AUC = 0.750, sensitivity = 73.5%, specificity = 80.0%) and sum average (0.751, 70.6%, 80.0%) had relatively higher specificity, and all had AUC >0.7. MD had the highest diagnostic performance, with AUC = 0.878, sensitivity = 94.1%, specificity = 75.0%, PPV = 86.5%, and NPV = 88.2%.
Data Conclusion: MRTA on T 2 FLAIR images may be helpful in identifying oligodendroglioma, IDH-mutant, and 1p/19q-codeleted.
Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017.
(© 2017 International Society for Magnetic Resonance in Medicine.)
