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Tytuł:
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Photobiomodulation therapy protects skeletal muscle and improves muscular function of mdx mice in a dose-dependent manner through modulation of dystrophin.
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Autorzy:
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Albuquerque-Pontes GM; Laboratory of Phototherapy in Sports and Exercise, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.; Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Casalechi HL; Laboratory of Phototherapy in Sports and Exercise, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.; Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Tomazoni SS; Masters and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, São Paulo, Brazil.
Serra AJ; Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Ferreira CSB; Laboratory of Phototherapy in Sports and Exercise, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Brito RBO; Postgraduate Program in Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
de Melo BL; Postgraduate Program in Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Vanin AA; Laboratory of Phototherapy in Sports and Exercise, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.; Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Monteiro KKDS; Laboratory of Phototherapy in Sports and Exercise, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.; Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Dellê H; Postgraduate Program in Medicine, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Frigo L; Biological Sciences and Health Center, Cruzeiro do Sul University, São Paulo, Brazil.
Marcos RL; Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
de Carvalho PTC; Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.; Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Leal-Junior ECP; Laboratory of Phototherapy in Sports and Exercise, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil. .; Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil. .
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Źródło:
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Lasers in medical science [Lasers Med Sci] 2018 May; Vol. 33 (4), pp. 755-764. Date of Electronic Publication: 2017 Dec 05.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: London : Springer
Original Publication: London : Baillière Tindall, c1986-
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MeSH Terms:
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Dystrophin/*metabolism
Low-Level Light Therapy/*methods
Muscle, Skeletal/*physiopathology
Muscle, Skeletal/*radiation effects
Muscular Dystrophy, Duchenne/*physiopathology
Muscular Dystrophy, Duchenne/*radiotherapy
Animals ; Dose-Response Relationship, Radiation ; Gene Expression Regulation ; Mice, Inbred C57BL ; Mice, Inbred mdx ; Placebos ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
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References:
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Grant Information:
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2010/52404-0 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2014/05203-0 Fundação de Amparo à Pesquisa do Estado de São Paulo (BR)
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Contributed Indexing:
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Keywords: Duchenne muscular dystrophy; Dystrophies; Light-emitting diodes; Low-level laser therapy; Phototherapy
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Substance Nomenclature:
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0 (Dystrophin)
0 (Placebos)
0 (RNA, Messenger)
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Entry Date(s):
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Date Created: 20171207 Date Completed: 20180622 Latest Revision: 20181202
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Update Code:
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20240105
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DOI:
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10.1007/s10103-017-2405-5
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PMID:
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29209866
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This study aimed to analyze the protective effects of photobiomodulation therapy (PBMT) with combination of low-level laser therapy (LLLT) and light emitting diode therapy (LEDT) on skeletal muscle tissue to delay dystrophy progression in mdx mice (DMD mdx ). To this aim, mice were randomly divided into five different experimental groups: wild type (WT), placebo-control (DMD mdx ), PBMT with doses of 1 J (DMD mdx ), 3 J (DMD mdx ), and 10 J (DMD mdx ). PBMT was performed employing a cluster probe with 9 diodes (1 x 905nm super-pulsed laser diode; 4 x 875nm infrared LEDs; and 4 x 640nm red LEDs, manufactured by Multi Radiance Medical®, Solon - OH, USA), 3 times a week for 14 weeks. PBMT was applied on a single point (tibialis anterior muscle-bilaterally). We analyzed functional performance, muscle morphology, and gene and protein expression of dystrophin. PBMT with a 10 J dose significantly improved (p < 0.001) functional performance compared to all other experimental groups. Muscle morphology was improved by all PBMT doses, with better outcomes with the 3 and 10 J doses. Gene expression of dystrophin was significantly increased with 3 J (p < 0.01) and 10 J (p < 0.01) doses when compared to placebo-control group. Regarding protein expression of dystrophin, 3 J (p < 0.001) and 10 J (p < 0.05) doses also significantly showed increase compared to placebo-control group. We conclude that PBMT can mainly preserve muscle morphology and improve muscular function of mdx mice through modulation of gene and protein expression of dystrophin. Furthermore, since PBMT is a non-pharmacological treatment which does not present side effects and is easy to handle, it can be seen as a promising tool for treating Duchenne's muscular dystrophy.