Ferulic acid protects against radiation-induced testicular damage in male rats: impact on SIRT1 and PARP1.

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Tytuł:: Ferulic acid protects against radiation-induced testicular damage in male rats: impact on SIRT1 and PARP1.
Autorzy:: El-Mesallamy HO; Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt. hala_.
Gawish RA; Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.
Sallam AM; Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Fahmy HA; Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.
Nada AS; Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.
Źródło:: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2018 Mar; Vol. 25 (7), pp. 6218-6227. Date of Electronic Publication: 2017 Dec 14.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed
MeSH Terms:: Coumaric Acids/*pharmacology
Poly (ADP-Ribose) Polymerase-1/*metabolism
Radiation Injuries, Experimental/*prevention & control
Radiation-Protective Agents/*pharmacology
Sirtuin 1/*metabolism
Testis/*drug effects
Animals ; Gamma Rays ; Male ; Oxidative Stress/drug effects ; Oxidative Stress/radiation effects ; Poly (ADP-Ribose) Polymerase-1/genetics ; Radiation Injuries, Experimental/metabolism ; Rats ; Rats, Sprague-Dawley ; Sirtuin 1/genetics ; Spermatogenesis/drug effects ; Spermatozoa/drug effects ; Spermatozoa/metabolism ; Testis/metabolism ; Testis/radiation effects
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Contributed Indexing:: Keywords: Fertility; Ferulic acid; Gamma-radiation; Oxidative stress; PARP1; SIRT1
Substance Nomenclature:: 0 (Coumaric Acids)
0 (Radiation-Protective Agents)
AVM951ZWST (ferulic acid)
EC 2.4.2.30 (Parp1 protein, rat)
EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1)
EC 3.5.1.- (Sirt1 protein, rat)
EC 3.5.1.- (Sirtuin 1)
Entry Date(s):: Date Created: 20171216 Date Completed: 20181126 Latest Revision: 20181126
Update Code:: 20240104
DOI:: 10.1007/s11356-017-0873-6
PMID:: 29243149
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Ionizing radiation is a major contributor to male infertility by destroying spermatogenesis. Therefore, the need for an effective radio-protective agent is evident. The objective of the present study was to investigate the potential radio-protective effect of ferulic acid (FA) on radiation-induced testicular damage. Mature male Sprague-Dawley rats were either exposed to a single-dose gamma radiation (5 Gy) and/or treated with FA (50 mg/kg), daily for 7 days before irradiation. Sirtuin1 (SIRT1), poly (ADP-ribose) polymerase 1 (PARP1), cytosolic calcium content, and the male reproductive functions (sperm head abnormality) as well as oxidative stress markers were assessed 7 days after irradiation. FA significantly maintained active spermatogenesis. Moreover, it reversed the oxidative stress effects of irradiation. The irradiated group showed marked elevation in both PARP1 expression and activity as well as in cytosolic calcium concentration, whereas SIRT1 activity and expression markedly decreased; in contrast, FA treatment prevented these alterations. Results of histopathological examination of testicular tissues indicated coincidence with those recorded by biochemical analyses. Our data show for the first time that FA had radio-protective effect against radiation-induced testicular damage. It improved spermatogenesis through increasing testicular SIRT1 and testosterone levels and decreasing oxidative stress, PARP1, and cytosolic calcium.

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