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Tytuł:
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Association between the time after transplantation and different immunosuppressive medications with dental and periodontal treatment need in patients after solid organ transplantation.
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Autorzy:
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Schmalz G; Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
Wendorff H; Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
Berisha L; Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
Meisel A; Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
Widmer F; Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
Marcinkowski A; Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
Teschler H; Department of Pneumology, West German Lung Center, Ruhrlandklinik, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Sommerwerck U; Department of Pneumology, West German Lung Center, Ruhrlandklinik, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Haak R; Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
Kollmar O; Department of General and Visceral Surgery, HELIOS Dr. Horst Schmidt-Kliniken, Wiesbaden, Germany.
Ziebolz D; Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
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Źródło:
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Transplant infectious disease : an official journal of the Transplantation Society [Transpl Infect Dis] 2018 Apr; Vol. 20 (2), pp. e12832. Date of Electronic Publication: 2018 Feb 21.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Copenhagen : Munksgaard, c1999-
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MeSH Terms:
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Organ Transplantation*
Transplant Recipients*
Immunosuppressive Agents/*adverse effects
Periodontal Diseases/*etiology
Stomatognathic Diseases/*etiology
Adult ; Aged ; Cohort Studies ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Middle Aged
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Contributed Indexing:
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Keywords: caries; dental treatment need; immunosuppression; oral health; organ transplantation; periodontal treatment need; periodontitis
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Substance Nomenclature:
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0 (Immunosuppressive Agents)
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Entry Date(s):
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Date Created: 20180124 Date Completed: 20180917 Latest Revision: 20180917
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Update Code:
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20240105
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DOI:
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10.1111/tid.12832
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PMID:
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29359871
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Objective: The aim of this study was to investigate the association of time after transplantation and different immunosuppressive medications with dental and periodontal treatment needs in patients after solid organ transplantation (SOT).
Methods: After lung, liver, or kidney transplantation, patients were included and divided into subgroups based on the time after SOT (0-1, 1-3, 3-6, 6-10, and >10 years) and immunosuppression (tacrolimus, cyclosporine, mycophenolate, glucocorticoids, sirolimus, and monotherapy vs combination). Dental treatment need was determined by the presence of carious lesions, while periodontal treatment need was diagnosed based on a Periodontal Screening index score of 3-4. The overall treatment need included both the dental and/or periodontal treatment needs. Statistical analysis was performed using the Kruskal-Wallis test and chi-squared test (P < .05).
Results: A total of 169 patients were included after SOT. A dental treatment need of 44%, a periodontal treatment need of 71%, and an overall treatment need of 84% were detected in the total cohort. Only patients with >10 years after SOT had a lower dental treatment need compared to the other groups (P = .02). All other comparisons of dental, periodontal, and overall treatment needs were comparable between subgroups depending on time since SOT. Furthermore, no statistically significant differences were found in terms of the dental, periodontal, or overall treatment needs following the administration of different immunosuppressive medications.
Conclusion: The high treatment need of patients after SOT, irrespective of the time since transplantation, suggests insufficient dental and periodontal treatment before and maintenance after organ transplantation. Furthermore, immunosuppressive medication was not associated with the treatment need.
(© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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