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Tytuł pozycji:

A New Method of Producing a Natural Antibacterial Peptide by Encapsulated Probiotics Internalized with Inulin Nanoparticles as Prebiotics.

Tytuł:
A New Method of Producing a Natural Antibacterial Peptide by Encapsulated Probiotics Internalized with Inulin Nanoparticles as Prebiotics.
Autorzy:
Cui LH; Department of Animal Science, College of Agriculture Science, Yanbian University, Yanji, Jilin 133002, P.R. China.; Co-Innovation Center of Beef Cattle Science and Industry Technology, Yanbian University, Yanji, Jilin 133002, P.R. China.
Yan CG; Department of Animal Science, College of Agriculture Science, Yanbian University, Yanji, Jilin 133002, P.R. China.; Co-Innovation Center of Beef Cattle Science and Industry Technology, Yanbian University, Yanji, Jilin 133002, P.R. China.
Li HS; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Kim WS; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Hong L; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Kang SK; Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Republic of Korea.
Choi YJ; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Cho CS; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Źródło:
Journal of microbiology and biotechnology [J Microbiol Biotechnol] 2018 Apr 28; Vol. 28 (4), pp. 510-519.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: 2002- : Seoul : Korean Society for Microbiology and Biotechnology
Original Publication: Seoul : Korean Society for Applied Microbiology, 1991-2001.
MeSH Terms:
Inulin/*pharmacology
Nanoparticles/*chemistry
Peptides/*pharmacology
Prebiotics/*microbiology
Probiotics/*pharmacology
Alginates ; Animals ; Anti-Bacterial Agents/administration & dosage ; Antibiosis ; Capsules/pharmacology ; Chitosan ; Coculture Techniques ; Drug Combinations ; Fatty Acids, Volatile/analysis ; Glucuronic Acid ; Hexuronic Acids ; Inulin/analysis ; Inulin/chemistry ; Inulin/isolation & purification ; Particle Size ; Pediocins/pharmacology ; Pediococcus acidilactici/physiology ; Peptides/administration & dosage ; Probiotics/administration & dosage ; Salmonella/drug effects
Contributed Indexing:
Keywords: Pediocin; Probiotics; antibacterial; inulin nanoparticles; microcapsule
Substance Nomenclature:
0 (Alginates)
0 (Anti-Bacterial Agents)
0 (Capsules)
0 (Drug Combinations)
0 (Fatty Acids, Volatile)
0 (Hexuronic Acids)
0 (Pediocins)
0 (Peptides)
0 (Prebiotics)
8A5D83Q4RW (Glucuronic Acid)
9005-80-5 (Inulin)
9012-76-4 (Chitosan)
Entry Date(s):
Date Created: 20180201 Date Completed: 20180917 Latest Revision: 20181202
Update Code:
20240105
DOI:
10.4014/jmb.1712.12008
PMID:
29385662
Czasopismo naukowe
Synbiotics are a combination of probiotics and prebiotics, which lead to synergistic benefits in host welfare. Probiotics have been used as an alternative to antibiotics. Among the probiotics, Pediococcus acidilactici (PA) has shown excellent antimicrobial activity against Salmonella Gallinarum (SG) as a major poultry pathogen and has improved the production performances of animals. Inulin is widely used as a prebiotic for the improvement of animal health and growth. The main aim of this study is to investigate the effect of the antimicrobial activity of inulin nanoparticles (INs)-internalized PA encapsulated into alginate/chitosan/alginate (ACA) microcapsules (MCs) in future in vivo application. The prepared phthalyl INs (PINs) were characterized by DLS and FE-SEM. The contents of phthal groups in phthalyl inulin were estimated by ¹H-NMR measurement as 25.1 mol.-%. The sizes of the PINs measured by DLS were approximately 203 nm. Internalization into PA was confirmed by confocal microscopy and flow cytometry. Antimicrobial activity of PIN-internalized probiotics encapsulated into ACA MCs was measured by co-culture antimicrobial assays on SG. PIN-internalized probiotics had a higher antimicrobial ability than that of ACA MCs loaded with PA/inulin or PA. Interestingly, when PINs were treated with PA and encapsulated into ACA MCs, as a natural antimicrobial peptide, pediocin was produced much more in the culture medium compared with other groups inulin-loaded ACA MCs and PA-encapsulated into ACA MCs.

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