Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Tytuł pozycji:

Equilibrium biopartitioning of organic anions - A case study for humans and fish.

Tytuł :
Equilibrium biopartitioning of organic anions - A case study for humans and fish.
Autorzy :
Goss KU; Helmholtz Centre for Environmental Research UFZ, Department of Analytical Environmental Chemistry, Permoserstr. 15, D-04318 Leipzig, Germany; University of Halle-Wittenberg, Institute of Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle, Germany. Electronic address: .
Bittermann K; Helmholtz Centre for Environmental Research UFZ, Department of Analytical Environmental Chemistry, Permoserstr. 15, D-04318 Leipzig, Germany.
Henneberger L; Helmholtz Centre for Environmental Research UFZ, Department of Cell Toxicology, Permoserstr. 15, D-04318 Leipzig, Germany.
Linden L; Helmholtz Centre for Environmental Research UFZ, Department of Analytical Environmental Chemistry, Permoserstr. 15, D-04318 Leipzig, Germany.
Pokaż więcej
Źródło :
Chemosphere [Chemosphere] 2018 May; Vol. 199, pp. 174-181. Date of Electronic Publication: 2018 Feb 06.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford, New York, : Pergamon Press.
MeSH Terms :
Models, Biological*
Albumins/*metabolism
Fishes/*metabolism
Organic Chemicals/*metabolism
Water Pollutants, Chemical/*metabolism
Absorption, Physiological ; Animals ; Anions ; Humans ; Hydrogen-Ion Concentration ; Membrane Lipids/metabolism ; Organ Specificity ; Organic Chemicals/toxicity ; Species Specificity ; Toxicokinetics ; Water Pollutants, Chemical/toxicity
Contributed Indexing :
Keywords: Bioaccumulation; Bioconcentration; Chemical regulation; Organic anions; Partitioning; Risk assessment
Substance Nomenclature :
0 (Albumins)
0 (Anions)
0 (Membrane Lipids)
0 (Organic Chemicals)
0 (Water Pollutants, Chemical)
Entry Date(s) :
Date Created: 20180214 Date Completed: 20180607 Latest Revision: 20180607
Update Code :
20210623
DOI :
10.1016/j.chemosphere.2018.02.026
PMID :
29438944
Czasopismo naukowe
In this work we combine partition coefficients between water and membrane lipid, storage lipid, the plasma protein albumin as well as structural protein with the tissue dependent fraction of the respective phases in order to obtain a clearer picture on the relevance of various biological tissues for the bioaccumulation of 31 organic anions. Most of the partition coefficients are based on experimental data, supplemented by some predicted ones. The data suggest that the plasma protein, albumin, will be the major sorption matrix in mammals. Only small fractions of the studied chemicals will occur freely dissolved in an organism. For the investigated acids with pKa <5, partitioning is dominated by the ionic species rather than the corresponding neutral species. Bioconcentration in fish is not expected to occur for many of these acids unless pH in the aqueous environment is low or specific sorption mechanisms are relevant. In contrast, biomagnification in terrestrial mammals would be expected for most organic anions if they are not sufficiently metabolized. We conclude that sorption is important for the toxicokinetics of ionizable organic chemicals and the dominating sorbing matrices are quite different from those for neutral species.
(Copyright © 2018. Published by Elsevier Ltd.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies