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Tytuł pozycji:

ADHD and maturation of brain white matter: A DTI study in medication naive children and adults.

Tytuł :
ADHD and maturation of brain white matter: A DTI study in medication naive children and adults.
Autorzy :
Bouziane C; Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands.
Caan MWA; Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands.
Tamminga HGH; Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.
Schrantee A; Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands.
Bottelier MA; Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Child- and Adolescent Psychiatry, Triversum, Alkmaar, The Netherlands.
de Ruiter MB; Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kooij SJJ; PsyQ, Psycho-medical Program, Expertise Center Adult ADHD, Den Haag, The Netherlands.
Reneman L; Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Brain Imaging Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: .
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Źródło :
NeuroImage. Clinical [Neuroimage Clin] 2017 Sep 29; Vol. 17, pp. 53-59. Date of Electronic Publication: 2017 Sep 29 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: [Amsterdam] : Elsevier
MeSH Terms :
Diffusion Tensor Imaging*
Attention Deficit Disorder with Hyperactivity/*diagnostic imaging
Brain/*diagnostic imaging
Brain/*growth & development
White Matter/*diagnostic imaging
Adult ; Age Factors ; Analysis of Variance ; Anisotropy ; Case-Control Studies ; Child ; Female ; Humans ; Image Processing, Computer-Assisted ; Male ; Neuropsychological Tests ; Psychiatric Status Rating Scales ; Young Adult
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Contributed Indexing :
Keywords: ADHD*; Age*; Brain development: ADHD medications*; Diffusion tensor imaging*
Entry Date(s) :
Date Created: 20180313 Date Completed: 20190201 Latest Revision: 20210109
Update Code :
20210210
PubMed Central ID :
PMC5842546
DOI :
10.1016/j.nicl.2017.09.026
PMID :
29527472
Czasopismo naukowe
Several diffusion tensor imaging (DTI) studies in attention deficit hyperactivity disorder (ADHD) have shown a delay in brain white matter (WM) development. Because these studies were mainly conducted in children and adolescents, these WM abnormalities have been assumed, but not proven to progress into adulthood. To provide further insight in the natural history of WM maturation delay in ADHD, we here investigated the modulating effect of age on WM in children and adults. 120 stimulant-treatment naive male ADHD children (10-12 years of age) and adults (23-40 years of age) with ADHD (according to DSM-IV; all subtypes) were included, along with 23 age and gender matched controls. Fractional anisotropy (FA) values were compared throughout the WM by means of tract-based spatial statistics (TBSS) and in specific regions of interest (ROIs). On both TBSS and ROI analyses, we found that stimulant-treatment naive ADHD children did not differ in FA values from control children, whereas adult ADHD subjects had reduced FA values when compared to adult controls in several regions. Significant age × group interactions for whole brain FA (p = 0.015), as well as the anterior thalamic radiation (p = 0.015) suggest that ADHD affects the brain WM age-dependently. In contrast to prior studies conducted in medicated ADHD children, we did not find WM alterations in stimulant treatment naïve children, only treatment-naïve adults. Thus, our findings suggest that the reported developmental delay in WM might appear after childhood, and that previously reported differences between ADHD children and normal developing peers could have been attributed to prior ADHD medications, and/or other factors that affect WM development, such as age and gender.

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